Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 347.00 | |
50 mg | In stock | $ 578.00 | |
100 mg | In stock | $ 798.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist. |
In vivo | Sultopride and sulpiride are both chemically similar benzamide derivatives and selective antagonists of dopamine D2 receptors.?However, these drugs differ in clinical properties.?We compared the effects of sultopride and sulpiride on dopamine turnover in rats following the administration of these drugs alone or in combination with apomorphine.?The administration of sultopride or sulpiride markedly accelerated dopamine turnover in the rat brain.?The increase in the level of dopamine metabolites in the striatum was more marked in the sultopride-treated rats.?Sulpiride affected the limbic dopamine receptors preferentially, whereas sultopride affected the striatal and the limbic dopamine receptors equally.?A low dose of apomorphine induced a reduction in the concentration of dopamine metabolites in the striatum and the nucleus accumbens by approximately 55%, but not in the medial prefrontal cortex.?Sultopride was more effective in preventing an apomorphine-induced reduction in dopamine metabolite levels. |
Synonyms | LIN-1418 hydrochloride |
Molecular Weight | 390.93 |
Formula | C17H27ClN2O4S |
CAS No. | 23694-17-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (127.90 mM)
You can also refer to dose conversion for different animals. More
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Sultopride hydrochloride 23694-17-9 GPCR/G Protein Neuroscience Dopamine Receptor dopamine Sultopride LIN-1418 hydrochloride LIN 1418 Hydrochloride LIN-1418 LIN 1418 HVA LIN1418 Inhibitor striatum LIN1418 Hydrochloride LIN-1418 Hydrochloride receptor inhibit DOPAC Sultopride Hydrochloride levels inhibitor