insulin-induced — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9266	Fatostatin		Lipid , Fatty Acid Synthase
	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.		Lipid , Fatty Acid Synthase
T6832	Fatostatin hydrobromide	Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1 , Fatty Acid Synthase
	Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.		NPC1L1 , Fatty Acid Synthase
TP1376	GLP-1(7-37) acetate(106612-94-6 free base)	GLP-1(7-37) acetate	Others , Glucagon Receptor
	Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion.		Others , Glucagon Receptor
T4785	Oxfenicine	4-Hydroxy-L-phenylglycine	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) is a carnitine palmitoyltransferase-1 inhibitor. Oxfenicine improves whole-body glucose tolerance and insulin sensitivity in high-fat diet-induced obese mouse with insulin resistanc...		Others
T3984	GLP-1(7-36), amide	MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide	Glucagon Receptor
	GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-...		Glucagon Receptor
T8773	MID-1		Others , IGF-1R
	MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet...		Others , IGF-1R
T13867	RH01386		Others
	RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ...		Others
TP2209L	Xenin 8 acetate	Xenin 8 acetate (117442-28-1 Free base)	IGF-1R
	Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family. Xenin 8 acetate augments Arginine-induced insulin release (by 40%) and potentiates the glucagon responses to both Arginine (b...		IGF-1R
TN2215	Taurochenodeoxycholic acid sodium	Sodium taurochenodeoxycholate	Apoptosis , Endogenous Metabolite
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and...		Apoptosis , Endogenous Metabolite
T15368L	Galantide acetate	Galantide acetate(138579-66-5 Free base)	Neuropeptide Y Receptor
	Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in t...		Neuropeptide Y Receptor
T2160	Suramin Sodium Salt	BAY-205,Suramin hexasodium salt,NF-060	Apoptosis , Phosphatase , SARS-CoV , Sirtuin , Reverse Transcriptase , Topoisomerase , Parasite
	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth f...
T3123	Allicin		ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
TP1141	GLP-1(7-36), amide acetate	GLP-1(7-36) Acetate,Human GLP-1-(7-36)-amide Acetate
	GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.
TN3511	Bi-linderone		Others
	Bi-linderone shows significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.		Others
T34600	Secretin (1-6)	Secretin,N-terminal hexapeptide
	Secretin (1-6) is the N-terminal part of secretin. It can produce vitro glucose-dependent insulin release induced by secretin.
T37892	GLP-1(7-36), amide TFA
	GLP-1(7-36), amide TFA is a prominent intestinal hormone known to stimulate glucose-induced insulin secretion from β cells[1].
T26617	AMG-221	AMG221
	AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG-221 decreased fed blood glucose and insulin levels and reduced body weight in diet-induced obesity mice.
T27324	FK614	FK 614,ATx-08-001,ATx-08001,FK-614
	FK-614 is a selective agonist of peroxisome proliferator-activated receptor gamma. FK-614 improves peripheral glucose utilization while decreases hepatic insulin extraction in alloxan-induced diabetic dogs.
T30261	AZD6482 (S-isomer)	AZD-6482,AZD 6482,AZD6482 (S),AZD6482
	AZD6482 (S-isomer) is a potent, selective, ATP-competitive PI3Kβ inhibitor (IC(50) 0.01 μm), which can inhibit insulin-induced in vitro glucose uptake by human adipocytes (IC(50) is 4.4 μm).
T76634	(Sar1,Ile4,8)-Angiotensin II
	(Sar1,Ile4,8)-Angiotensin II is a functionally selective agonist for the angiotensin II type 1 receptor (AT1R), enhancing insulin-stimulated signaling of the insulin receptor (IR) and glycogen synthesis. It boosts the in...