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Fatostatin hydrobromide

Catalog No. T6832 CAS 298197-04-3

Synonyms: Fatostatin HBr, Fatostatin A, Fatostatin A HBr, Fatostatin

Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.

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Fatostatin hydrobromide Chemical Structure

Fatostatin hydrobromide, CAS 298197-04-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 67.00
25 mg	In stock	$ 121.00
50 mg	In stock	$ 202.00
100 mg	In stock	$ 343.00
200 mg	In stock	$ 497.00
500 mg	In stock	$ 829.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.91%

Purity: 98.04%

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Description	Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
In vitro	Fatostatin inhibits the insulin-induced adipogenesis of 3T3-L1 cells and the serum-independent growth of human androgen-independent prostate cancer (DU145) cells. Fatostatin suppresses cell proliferation and anchorage-independent colony formation in both androgen-responsive LNCaP and androgen-insensitive C4-2B prostate cancer cells. Fatostatin blocks the activation of SREBPs in cells in tissue culture.Fatostatin also reduced in vitro invasion and migration in both cell lines. Further, fatostatin causes G2/M cell cycle arrest and induces apoptosis by increasing caspase-3/7 activity and the cleavages of caspase-3 and PARP.
In vivo	Fatostatin significantly inhibits subcutaneous C4-2B tumor growth and markedly decreases serum PSA level compared to the control group. Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
Cell Research	Cell lines: CHO-K1 cells. Concentrations: 20 μM. Incubation Time: 20 h. Method: On day 0,CHO-K1 cells are plated out onto a 96-well plate in medium A.On day 2,the cells are transiently cotransfected with pCMV-PLAP-BP2(513–1141),pCMV-SCAP,and pAc-β-gal,using Lipofectamine reagent.After incubation for 5 hr,the cells are washed with PBS and then incubated in medium B,in the absence or presence of fatostatin (20 μM) or sterols (10 μg/mL cholesterol and 1 μg/mL 25-hydroxycholesterol).After 20 hr of incubation,an aliquot of the medium is assayed for secreted alkaline phosphatase activity.The cells in each well are lysed and used for measurement of β-galactosidase activities.The alkaline phosphatase activity is normalized by the activity of β-galactosidase.
Animal Research	Animal Models: Obese (ob/ob) mice (C57BL/6J background). Formulation: 10% DMSO in PBS. Dosages: 30 mg/kg. Administration: intraperitoneal injection

Synonyms	Fatostatin HBr, Fatostatin A, Fatostatin A HBr, Fatostatin
Molecular Weight	375.33
Formula	C18H18N2S·HBr
CAS No.	298197-04-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7 mg/mL (18.65 mM)

Ethanol: 58 mg/mL (154.53 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Kamisuki S, et al. Chem Biol. 2009, 16(8):882-92. 2. Li X, et al. Mol Cancer Ther. 2014, 13(4):855-66. 3. Zhang Z, He J, Zhao Y, et al. Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ[J]. Acta Pharmacologica Sinica. 2020, 41(3): 373-382.

Citations

1. Zhang Z, He J, Zhao Y, et al. Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ. Acta Pharmacologica Sinica. 2020, 41(3): 373-382

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Ion Channel Inhibitor Library Anti-Obesity Compound Library Anti-Cancer Metabolism Compound Library Apoptosis Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Metabolism Compound Library Lipid Metabolism Compound Library

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Keywords

Fatostatin hydrobromide 298197-04-3 Membrane transporter/Ion channel Metabolism Fatty Acid Synthase NPC1L1 Golgi ob/ob inhibit prostate Fatostatin HBr SREBP-mediated cancer mice Fatostatin A Fatostatin A HBr insulin-induced adipogenesis Fatostatin Hydrobromide Fatty Acid Synthase (FASN) gene human expression Inhibitor 125B11 Fatostatin inhibitor

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