Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 303.00 | |
10 mg | In stock | $ 447.00 | |
25 mg | In stock | $ 738.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,380.00 | |
500 mg | In stock | $ 2,790.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 349.00 |
Description | RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses. |
In vitro | ATP levels in βTC6 cells treated with (tunicamycin) Tm increase by RH01386.RH01386 exhibits a EC50 value of 1.894 μM. RH01386 dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells. |
Molecular Weight | 424.4 |
Formula | C18H15F3N4O3S |
CAS No. | 301177-36-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (129.59 mM)
You can also refer to dose conversion for different animals. More
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RH01386 301177-36-6 Others RH 01386 βTC6 cells inhibit Apoptosis RH-01386 Inhibitor type 2 diabetes β cell inhibitor