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Galantide acetate

Catalog No. T15368L

Synonyms: Galantide acetate(138579-66-5 Free base)

Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide acetate dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide acetate appears to bind to a single population of SP receptors (KD~40 nM).

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Galantide acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 263.00
2 mg	In stock	$ 418.00
5 mg	In stock	$ 695.00
10 mg	In stock	$ 988.00
25 mg	In stock	$ 1,470.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,670.00

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Purity: 97.8%

Biological Description

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Storage & Solubility Information

Description	Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide acetate dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide acetate appears to bind to a single population of SP receptors (KD~40 nM).
In vitro	Galantide acetate do not activate the K+ conductance but produces a concentration-dependent antagonism (IC50=4 nM) of the galanin-induced increase in K+ conductance. Galantide acetate acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC50=16 nM) and the maximum inhibition produced by galantide is approximately 40%[3].
In vivo	Intracerebroventricular injection of Galantide acetate (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin[2]. Galantide acetate ameliorates mild acute pancreatitis (AP). Galantide acetate significantly reduces AP-induced hyperenzymemia by 41–49%[3]. Galantide acetate has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM[4].

Synonyms	Galantide acetate(138579-66-5 Free base)
Molecular Weight	2259.58
Formula	C106H155N25O28S

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Langel U, et al. Design of chimeric peptide ligands to galanin receptors and substance P receptors. Int J Pept Protein Res. 1992;39(6):516-522. 2. Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992;210(2):183-188. 3. Mulvaney JM, et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995;287(1):97-100.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

[D-Trp34]-Neuropeptide Y Acetate GALNON Neurokinin antagonist 1 Galnon TFA(475115-35-6(free base)) RFRP-1 (human) acetate(311309-25-8 free base) CYM2503 HT-2157 ML 154

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Keywords

Galantide acetate GPCR/G Protein Neuroscience Neuropeptide Y Receptor Galantide acetate(138579-66-5 Free base) Galantide Acetate inhibitor inhibit

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