factor-at — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0947	Dexamethasone acetate	Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471	Glucocorticoid Receptor , Mitophagy , IL Receptor , Annexin A , NOS , Antibacterial , Autophagy
	Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexa...
T3469	PCI-27483	PCI27483	Others
	PCI-27483 is an activated coagulation factor VIIa inhibitor with antithrombotic effects in a baboon model of arterial thrombosis. It also inhibits the growth of BxPC3 xenografts by 42% and 85% at doses of 60 and 90 mg/kg...		Others
T1823	IOX2	IOX 2,JICL38	HIF/HIF Prolyl-Hydroxylase
	IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).		HIF/HIF Prolyl-Hydroxylase
TP1820L	Osteogenic Growth Peptide, OGP acetate	Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)	Others
	Osteogenic Growth Peptide, OGP acetate is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic oste...		Others
T4567	Sulfaphenazole	Plisulfan,Raziosulfa,Depocid,Depotsulfonamide	P450 , Antibacterial
	Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...		P450 , Antibacterial
T22833	H-9 dihydrochloride		EGFR , 5-HT Receptor , PKA
	H-9 dihydrochloride is a potent protein kinase (PKA) inhibitor.H-9 Dihydrochloride significantly reduces the excitatory response to 5-HT at low concentrations.H-9 Dihydrochloride affects pharyngeal activity.H-9 Dihydroch...		EGFR , 5-HT Receptor , PKA
T12006	Metarrestin	ML246	DNA/RNA Synthesis
	Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (...		DNA/RNA Synthesis
TN2322	Yangambin		Calcium Channel , PAFR
	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti...		Calcium Channel , PAFR
T76810	Ganitumab	AMG 479	IGF-1R
	Ganitumab (AMG 479) is a highly potent monoclonal antibody to type 1 insulin-like growth factor receptor (IGF1R). Ganitumab is recognized to bind to IGF1R at low concentration with KD value of 0.22 nM. Ganitumab can inhi...		IGF-1R
T22297	Clindamycin hydrochloride monohydrate	Clindamycin alcoholate	Antibiotic
	Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentra...		Antibiotic
T38293	4-CPPC		Others
	4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).1It is selective for MIF-2 over MIF-1 (IC50= 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concen...		Others
T14775	Bragsin2	6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2	Others
	Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase acti...		Others
T31206	Darexaban	YM 150,Darexaban, Tanexaban,YM150	Factor Xa
	Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...		Factor Xa
T16500	PF-3450074	PF-74	HIV Protease
	PF-3450074 (PF-74) acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cleavage and polyadenylation specific factor 6) and NUP153 (nu...		HIV Protease
TN1567	Delphinidin chloride		Estrogen Receptor/ERR , VEGFR
	Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in va...		Estrogen Receptor/ERR , VEGFR
T0983L	DL-Penicillamine	3-Sulfanylvaline	Antibiotic
	DL-Penicillamine (3-Sulfanylvaline) is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. DL-Penicillamine is only found in individuals that have used or taken this drug. It...		Antibiotic
T26968	CCT036477	CCT 036477,CCT-036477
	CCT036477 is a selective inhibitor of wingless-type MMTV integration site family dependent transcription. CCT036477reduces the transcriptional activity of the T-cell factor and lymphoid enhancer factor transcription fact...
T35926	Bz-IEGR-pNA (acetate)
	Bz-IEGR-pNA is a colorimetric substrate for Factor Xa.1 Factor Xa preferentially binds to and cleaves the Ile-Glu-Gly-Arg (IEGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric d...
TN2763	2-Hydroxy-3-methoxybenzoic acid glucose ester		PAFR
	2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.		PAFR
T29190	YM-75466	YM 466,YM-466,YM75466,YM 75466,YM-75466 Free
	YM-75466 is a factor Xa inhibitor. YM-75466 did not prolong coagulation time even at the dose which exerted significant antithrombotic effects, while it decreased TAT level in plasma in a dose-dependent manner.