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Metarrestin

Metarrestin
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
Catalog No. T12006Cas No. 1443414-10-5
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Purity:99.04%
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Metarrestin

Catalog No. T12006Cas No. 1443414-10-5
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
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Pack SizePriceAvailabilityQuantity
2 mg$29In Stock
5 mg$48In Stock
10 mg$88In Stock
25 mg$188In Stock
50 mg$323In Stock
100 mg$467In Stock
200 mg$655In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Product Introduction

Bioactivity
Description
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
AliasML246
Chemical Properties
Molecular Weight474.6
FormulaC31H30N4O
Cas No.1443414-10-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.75 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1070 mL10.5352 mL21.0704 mL105.3519 mL
5 mM0.4214 mL2.1070 mL4.2141 mL21.0704 mL
10 mM0.2107 mL1.0535 mL2.1070 mL10.5352 mL

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