Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
Description | Metarrestin is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. |
Synonyms | ML246 |
Molecular Weight | 474.6 |
Formula | C31H30N4O |
CAS No. | 1443414-10-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 31.25 mg/mL (65.84 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Metarrestin 1443414-10-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis ML-246 breast perinucleolar HeLa ML246 nucleolar Inhibitor PANC1 orally metastatic transcription inhibit eEF1A2 PC3M compartment pancreatic ML 246 inhibitor