density — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2499	Torcetrapib	CP-529414	CETP
	Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces...		CETP
T5S0246	Pseudoprotodioscin		Others , Fatty Acid Synthase
	1. Pseudoprotodioscin has moderate cytotoxicity.		Others , Fatty Acid Synthase
T2334	Avanafil	TA1790	PDE
	Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.		PDE
T14667	BLT-1		Others , HCV Protease
	BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.		Others , HCV Protease
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T1510	Rosuvastatin calcium	ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.		Potassium Channel , HMG-CoA Reductase , Autophagy
T15549	Icosabutate		Others
	Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist...		Others
T0841	Bezafibrate	BM15075	PPAR
	Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.		PPAR
T13600	CDD3505	4-nitro-1-trityl-1H-imidazole	P450
	CDD3505 (4-nitro-1-trityl-1H-imidazole) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450
T25701	Levosemotiadil	SD 3212,SA 3212	LDL , Calcium Channel
	Levosemotiadil（SA 3212） is a novel calcium antagonist and a very potent inhibitor of low-density lipoprotein oxidation.Levosemotiadil may be used to prevent lethal cardiac arrhythmias.		LDL , Calcium Channel
T7617	Neurotensin(8-13)	Neurotensin(8-13)(3TFA)	Neurotensin Receptor
	Neurotensin(8-13)(3TFA) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.		Neurotensin Receptor
T11386L	Gemcabene	PD-72953	Others
	Gemcabene (PD-72953) is a lipid-lowering agent with anti-inflammatory activity. Gemcabene lowers low-density lipoprotein cholesterol and triglycerides, raises high-density lipoprotein cholesterol, and decreases pro-infla...		Others
T7617L	Neurotensin(8-13) 3TFA(60482-95-3(free base))		Neurotensin Receptor
	Neurotensin(8-13)(3TFA) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.		Neurotensin Receptor
T9379	L-Threonic acid magnesium salt		Others
	L-Threonic acid magnesium salt (L-TAMS) increases synapse density and memory ability in both aged rats and late stage Alzheimer’s disease (AD) model mice.		Others
T13601	CDD3506	1-TRITYL-1H-IMIDAZOL-4-AMINE	P450
	CDD3506 (1-TRITYL-1H-IMIDAZOL-4-AMINE) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450
T2845	Imperatorin	Ammidin,8-Isoamylenoxypsoralen,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen	TRP/TRPV Channel , AChR , AChE , NOD
	Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.		TRP/TRPV Channel , AChR , AChE , NOD
T1771	Ro 48-8071 fumarate		Others
	Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.		Others
T25450L	GGTI 2147 FA	GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)	Others
	GGTI 2147 FA, a selective GGT inhibitor, abolishes bicuculline-induced increase in dendritic spine density in hippocampal experiments and may reduce learning and memory abilities in mice.		Others
T20887	Atorvastatin Sodium	Lipitor	LDL , Aquaporin , HMG-CoA Reductase
	Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to ...		LDL , Aquaporin , HMG-CoA Reductase
T77697	BML-278	BML278,BML 278	Sirtuin , Histone Methyltransferase
	BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...		Sirtuin , Histone Methyltransferase