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Rosuvastatin calcium

Catalog No. T1510 CAS 147098-20-2

Synonyms: ZD 4522 Calcium, ZD4522, Rosuvastatin hemicalcium

Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.

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Rosuvastatin calcium, CAS 147098-20-2

Pack Size	Availability	Price/USD
25 mg	In stock	$ 34.00
50 mg	In stock	$ 47.00
100 mg	In stock	$ 84.00
200 mg	In stock	$ 129.00
500 mg	In stock	$ 216.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 98.85%

Purity: 98.62%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
Targets&IC50	HMG-CoA:11 nM
In vitro	In streptozotocin-induced diabetic rats, daily administration of Rosuvastatin (20 mg/kg) significantly reduces the content of very low-density lipoprotein (VLDL) within the body. Similarly, in male beagles with normal cholesterol levels, Rosuvastatin (3 mg/kg) effectively lowers the concentration of cholesterol in the plasma.
In vivo	In isolated rat hepatocytes (IC50=1.12 nM), Rosuvastatin acts as a high-affinity substrate for OATP-C, inhibiting cholesterol synthesis. Additionally, in endothelial cells, Rosuvastatin suppresses the expression and protein levels of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA by inhibiting the c-Jun N-terminal kinase and nuclear factor-kB.

Synonyms	ZD 4522 Calcium, ZD4522, Rosuvastatin hemicalcium
Molecular Weight	1001.14
Formula	2(C22H27FN3O6S)Ca
CAS No.	147098-20-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (199.77 mM), Heating is recommended.

References and Literature

1. Watanabe M, et al. Bioorg Med Chem, 1997, 5(2), 437-444.

Citations

1. Tan X D, Luo C F, Liang S Y.Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma.Journal of Chemotherapy.2024: 1-13. 2. Kowal-Chwast A, Gabor-Worwa E, Gaud N, et al.Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran.Pharmacological Reports.2024: 1-16.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Fluorochemical Library Bioactive Compound Library Clinical Compound Library NO PAINS Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rosuvastatin calcium 147098-20-2 Autophagy Membrane transporter/Ion channel Metabolism Potassium Channel HMG-CoA Reductase gene ZD 4522 Calcium lipoprotein Inhibitor ZD-4522 ZD4522 potential repolarization QTc Hsp70 related HMG-CoA Reductase (HMGCR) inhibit durations Rosuvastatin cholesterol hERG cardiac ZD 4522 low-density KcsA Rosuvastatin hemicalcium triglycerides action APDs inhibitor

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