cisplatin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1564	Cisplatin	cis-Diaminodichloroplatinum,CDDP	DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T82715	Cisplatin-resistant cells-IN-1
	Cisplatin-resistant cells-IN-1 (Compound 8) exhibits high cytotoxicity against Cisplatin-resistant cells and effectively diminishes metabolic activity at low nanomolar concentrations, with an IC50 ranging from 0.14 to 1....
TN1621	Eriodictyol-7-O-glucoside		Nrf2
	Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and a free radical scavenger with antioxidant activity in pistachio skin.		Nrf2
T10777	CG347B		HDAC
	CG347B is a selective inhibitor of HDAC6.		HDAC
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
TN1637	Eurycomalactone		Anti-infection , NF-κB
	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...		Anti-infection , NF-κB
TQ0211	Brusatol	(+)-Brusatol,NSC 172924	Others , Ferroptosis , Nrf2
	Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.		Others , Ferroptosis , Nrf2
T68105	Monohydroxycisplatin
	monohydroxycisplatin is a useful organic compound for research related to life sciences. The catalog number is T68105 and the CAS number is 101311-26-6.
T35300	Zeniplatin	Zeniplatinum	Others
	Zeniplatin (Zeniplatinum) is a new cisplatin complex with anticancer activity for the treatment of metastatic melanoma and kidney cancer.		Others
T36404L	PRLX-93936 HCL	PRLX-93936 hcl(903499-49-0 Free base)	Ferroptosis , Reactive Oxygen Species
	PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.		Ferroptosis , Reactive Oxygen Species
T4943	Monoolein	1-Oleoyl-rac-glycerol	Others , Endogenous Metabolite
	Monoolein (1-Oleoyl-rac-glycerol) is a surfactant that releases free glycerol and oleic acid upon hydrolysis. Monoolein has been used in liquid crystal studies and research shows that in the presence of monoolein, the pe...		Others , Endogenous Metabolite
T1058	Carboplatin	NSC 241240,CBDCA,JM-8	DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
	Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity.		DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
T1478	Ondansetron hydrochloride dihydrate	SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride	5-HT Receptor
	Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, a...		5-HT Receptor
TN3174	6-Methoxyflavanone	NSC50184	GABA Receptor
	6-Methoxyflavanone (6-MeOF) is A positive allosteric modulator of the GABA response of human recombinant GABA A receptor, with antianxiety and anti-inflammatory activity, and can be used to reduce cisplatin induced neuro...		GABA Receptor
T60904	ERCC1-XPF-IN-2		Others
	ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1].		Others
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T6381	Amifostine trihydrate	Ethyol trihydrate,WR2721,Amifostine	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.		Others , HIF/HIF Prolyl-Hydroxylase
T4434	Tirapazamine	Tirazone,Win59075,SR4233,SR259075	Others
	Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to oth...		Others
T14919	CDKI-73		Apoptosis , CDK
	CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effe...		Apoptosis , CDK
T2410	Nedaplatin	NSC 375101D	DNA/RNA Synthesis
	Nedaplatin (NSC-375101D) is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand...		DNA/RNA Synthesis