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Tirapazamine

Catalog No. T4434 CAS 27314-97-2

Synonyms: Tirazone, Win59075, SR4233, SR259075

Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.

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Tirapazamine, CAS 27314-97-2

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 44.00
50 mg	In stock	$ 61.00
100 mg	In stock	$ 102.00
200 mg	In stock	$ 162.00
500 mg	In stock	$ 268.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.87%

Purity: 99.05%

Purity: 96.65%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.
In vitro	Tirapazamine could downregulate HIF-1α expression by decreasing HIF-1α protein synthesis. The enhanced apoptosis induced by tirapazamine plus SN-38 (the active metabolite of irinotecan) was accompanied by increased mitochondrial depolarization and caspase pathway activation [1].
In vivo	The increased the anticancer efficacy of tirapazamine combined with irinotecan was further validated in a human liver cancer Bel-7402 xenograft mouse model [1]. Rats were intraperitoneally injected six times once a week with tirapazamine in two doses, 5 (5TP) and 10 mg/kg (10TP), while doxorubicin was administered in dose 1.8 mg/kg (DOX). Subsequent two groups received both drugs simultaneously (5TP+DOX and 10TP+DOX). Tirapazamine reduced heart lipid peroxidation and normalized RyR2 protein level altered by doxorubicin [2].

Synonyms	Tirazone, Win59075, SR4233, SR259075
Molecular Weight	178.15
Formula	C7H6N4O2
CAS No.	27314-97-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (280.66 mM)

References and Literature

1. Cai T Y, Liu X W, Zhu H, et al. Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1α[J]. Molecular cancer therapeutics, 2013: molcanther. 0490.2013. 2. Sliwinska J, Dudka J, Korga A, et al. Tirapazamine-Doxorubicin Interaction Referring to Heart Oxidative Stress and Ca< sup> 2[J]. Oxidative medicine and cellular longevity, 2012, 2012.

Citations

1. Liu C, Jia S, Tu L, et al. GSH-Responsive and Hypoxia-Activated Multifunctional Nanoparticles for Synergetically Enhanced Tumor Therapy. ACS Biomaterials Science & Engineering. 2022 2. Wu Z, Wang Y, Li L, et al.New insights into the antimicrobial action and protective therapeutic effect of tirapazamine towards Escherichia coli-infected mice.International Journal of Antimicrobial Agents.2023: 106923.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Pediatric Drug Library Clinical Compound Library Anti-Liver Cancer Compound Library ReFRAME Related Library NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tirapazamine 27314-97-2 Others inhibit SML-0552 Tirazone SML0552 SML 0552 SR-4233 Bioreductive Agent Win59075 Win-59075 Inhibitor Win 59075 SR 259075 SR4233 SR-259075 Anticancer Agent SR 4233 SR259075 inhibitor

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