cancers — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8890	653-47 hydrochloride		Epigenetic Reader Domain
	653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.		Epigenetic Reader Domain
T7589	Afamelanotide acetate	afamelanotide	Melanocortin Receptor
	Afamelanotide acetate is a synthetic α-melanocyte stimulating hormone analogue and first-in-class melanocortin-1 receptor agonist, used to for Erythropoietic Protoporphyria.		Melanocortin Receptor
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T13044	Mevociclib	SY-1365	CDK
	Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.		CDK
T12075	ML-180	SR1848	Others
	ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .		Others
T8740	COH-SR4	COH-SR4 (Mitochondria uncoupler SR4)	Others , AMPK
	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proli...		Others , AMPK
TP1097	Melanotan I	[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I	Others
	Melanotan I is a non-specific melanocortin receptor (MCR) agonist, an α-melanocyte-stimulating hormone (α-MSH) analog, which is injected subcutaneously to increase the amount of melanin in the skin Melanotan I is used as...		Others
T5349	SCR-1481B1	c-Met inhibitor 2	VEGFR , c-Met/HGFR
	SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitor		VEGFR , c-Met/HGFR
T9806	NVP-DKY709		Others
	NVP-DKY709 is a potent IKZF2 inhibitor for the treatment of cancers.		Others
T7598	Calcium N5-methyltetrahydrofolate	NSC173328	Others , Antifolate
	Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers		Others , Antifolate
T9089	FTO-IN-1	UUN44923	Others
	UUN44923 is a FTO inhibitor. It may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a h...		Others
T27454	GSK2008607		Raf
	GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.		Raf
T9175	Casein Kinase inhibitor A51		Apoptosis , Casein Kinase
	Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be used in the study of neck cancers, acute myeloid leukemia, b...		Apoptosis , Casein Kinase
T8343	8-Hydroxy-2'-deoxyguanosine	8-OHdG,8-Hydroxydeoxyguanosine,8-Hydroxy-2-Deoxyguanosine,2'-Deoxy-8-oxoguanosine,8 OHdG,8-Oxo-dG,8 Oxo dG,8-Oxo-2'-deoxyguanosine	Endogenous Metabolite
	8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases.		Endogenous Metabolite
T37422L	Ras Inhibitory Peptide acetate	Ras Inhibitory Peptide acetate(159088-48-9 Free base)	Ras
	Ras Inhibitory Peptide acetate is a peptide involved in the Ras-dependent signaling pathway that plays an important role in human cancers initiated by oncogenic receptors.		Ras
T2894	Norcantharidin	Norcantharadine,Endothall anhydride	EGFR , c-Met/HGFR
	Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.		EGFR , c-Met/HGFR
T5656	(±)-Norcantharidin	Endothall anhydride,Norcantharidin	EGFR , c-Met/HGFR
	(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.		EGFR , c-Met/HGFR
T63351L	MS8511 HCl	MS8511 HCl(2866408-21-9 Free base)	Histone Methyltransferase
	MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer activity and antiproliferative activity and reduces intrace...		Histone Methyltransferase
T2477	UNBS5162	UNBS 5162,UNBS-5162	CXCR , Autophagy
	UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.		CXCR , Autophagy
T12365	PARP/PI3K-IN-1		PARP , PI3K
	PARP/PI3K-IN-1 is a novel dual poly (ADP-ribose) polymerase (PARP) and phosphatidylinositol 3-kinase (PI3K) dual inhibitor with anticancer, antitumour and antiproliferative activities for the study of breast, pancreatic ...		PARP , PI3K