assay — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21343	PTZ-343	PTZ-343 sodium,PTZ 343	Others
	PTZ-343 is a potent enhancer of Luminol, acts as an electron transfer mediator, reacting with HRP-II to release HRP and a PTZ-343 radical, which oxidizes luminol anions to induce light emission.		Others
TN3112	5-Heneicosylresorcinol		NADPH-oxidase , Antifection
	5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against n...		NADPH-oxidase , Antifection
T10924	Cysteine protease inhibitor-2		Cysteine Protease
	Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively.		Cysteine Protease
T12347	P38-α MAPK-IN-1		p38 MAPK , Autophagy
	p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor(IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay).		p38 MAPK , Autophagy
T9693	TBAP-001		Raf
	TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.		Raf
T16727	Relacorilant	CORT 125134	Glucocorticoid Receptor
	Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-...		Glucocorticoid Receptor
T7225	AnaMorelin hydrochloride	RC-1291 hydrochloride,ONO-7643 hydrochloride	GHSR
	AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).		GHSR
T37591	IMP-1710		DUB
	IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.		DUB
T39785L	TH5427		NUDIX hydrolase
	TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).		NUDIX hydrolase
T12856	SC-26196		Others
	SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 µM in a rat liver microsomal assay, with antiinflammatory properties.		Others
T8930	CID44216842	KUC103479N-02	CDK , Ras
	CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT...		CDK , Ras
T1971	WAY-262611		Wnt/beta-catenin
	WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.		Wnt/beta-catenin
T5410	PD158780		EGFR
	PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR, ErbB2, ErbB3, and ErbB4 (IC50s: 8μM, 49 nM, 52 nM, and 52 nM in cell assay).		EGFR
T12589	PI3Kα/mTOR-IN-1		PI3K , mTOR
	PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively.		PI3K , mTOR
T13000	Src Inhibitor 3		Others , Src
	Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferation induced by T cell receptor signaling.		Others , Src
T6935	Nirogacestat	PF-03084014,PF-3084014,PF03084014,PF 03084014	Apoptosis , Gamma-secretase
	Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).		Apoptosis , Gamma-secretase
T4470	Pyridostatin TFA		DNA/RNA Synthesis
	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.		DNA/RNA Synthesis
T12128	Mutant IDH1-IN-2		Isocitrate Dehydrogenase (IDH)
	Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor		Isocitrate Dehydrogenase (IDH)
T4018	WST-8	WST8	Others
	WST-8 is a water-soluble tetrazolium dye, the sensitivity of the WST-8(WST8)-based assay is higher than the conventional MTS-based assay.		Others
T20490	Z-Arg(Z)2-OH	NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine	Others
	Z-Arg(Z)2-OH can be used in the assay to screen proteolytic activities in mite homogenates.		Others