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GPCR/G Protein GHSR AnaMorelin hydrochloride

AnaMorelin hydrochloride

Catalog No. T7225   CAS 861998-00-7
Synonyms: RC-1291 hydrochloride, ONO-7643 hydrochloride

Anamorelin hydrochloride is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).

AnaMorelin hydrochloride, CAS 861998-00-7
Pack Size Availability Price/USD Quantity
2 mg In stock 57.00
5 mg In stock 80.00
10 mg In stock 113.00
25 mg In stock 168.00
50 mg In stock 210.00
100 mg In stock 275.00
1 mL * 10 mM (in DMSO) In stock 102.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Anamorelin hydrochloride is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).
Targets&IC50 ghrelin receptor(in the FLIPR assay) : 0.74 nM(EC50),  
In vivo In rats, AnaMorelin hydrochloride(ANAM) significantly and dose-dependently increased FI and BW at all dose levels compared with control, and significantly increased GH levels at 10 or 30 mg/kg doses. Increases in GH and IGF-1 levels were observed following ANAM administration in pigs[1].
Animal Research
Fluorescent imaging plate reader and binding assays in HEK293 and baby hamster kidney cells determined the agonist and antagonist activity of ANAM, and its affinity for the ghrelin receptor. Rat pituitary cells were incubated with ANAM to evaluate its effect on growth hormone (GH) release. In vivo, rats were treated with ANAM 3, 10, or 30 mg/kg, or control orally, once daily for 6 days to evaluate the effect on food intake (FI) and body weight (BW), and once to assess GH response. In pigs, single (3.5 mg/kg) or continuous (1 mg/kg/day) ANAM doses were administered to assess GH and insulin-like growth factor (IGF-1) response[1].
Synonyms RC-1291 hydrochloride , ONO-7643 hydrochloride
Purity 98.00%
Molecular Weight 583.16
Formula C31H43ClN6O3
CAS No. 861998-00-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 28 mg/mL (48.01 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Pietra C , Takeda Y , Tazawa-Ogata N , et al. Anamorelin HCI (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile[J]. Journal of Cachexia, Sarcopenia and Muscle, 2014, 5(4). 2. Currow D C , Skipworth R J . The emerging role of anamorelin hydrochloride in the management of patients with cancer anorexia-cachexia[J]. Future Oncology, 2017:fon-2017-0141.

Related Products

Related compounds with same targets
Anamorelin JMV 2959 hydrochloride TC-G-1008 Pralmorelin Pralmorelin acetate 158861-67-7(free base) Ibutamoren Mesylate AnaMorelin hydrochloride GHRP-6 acetate

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