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SC-26196

Catalog No. T12856 CAS 218136-59-5

SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties.

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SC-26196, CAS 218136-59-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 62.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 148.00
25 mg	In stock	$ 246.00
50 mg	In stock	$ 363.00
100 mg	In stock	$ 539.00

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Purity: 99.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties.
Targets&IC50	Delta6 desaturase (rat liver microsomal assay):0.2 µM
In vitro	The FADS2 inhibitor SC26196 reduced PBMC, but not Jurkat cell, proliferation suggesting PUFA synthesis is involved in regulating mitosis in PBMCs[1].

Molecular Weight	423.55
Formula	C27H29N5
CAS No.	218136-59-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4 mg/mL (9.44 mM), Sonication is recommended.

References and Literature

1. Sibbons CM, et al. Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of 2. Obukowicz MG, et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther. 1998 Oct;287(1):157-66.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Fibrosis Compound Library Bioactive Compound Library Orally Active Compound Library Anti-Aging Compound Library Bioactive Compounds Library Max

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SC-26196 218136-59-5 Others SC 26196 disease inhibit Delta6 FADS2 desaturase D6D SC26196 inflammatory Inhibitor Antiinflammatory inhibitor

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