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Search Results for " arterial "

20

Compounds

Cat No. Product Name Synonyms Targets
T12268 NTP42 Prostaglandin Receptor , PPAR
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
T11831 LDN-27219 Others
LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.
T11339 Furegrelate sodium U-63557A PPAR
Furegrelate sodium (U-63557A) is a selective thromboxane synthase inhibitor with oral activity. Furegrelate sodium(U-63557A) inhibits thromboxane A2 (TXA2) synthase in human platelet microsomes with an IC50 of 15 nM.
T0308 Etidronic acid HEDPA,Etidronate,HEDP Apoptosis , Phosphatase , Others , HBV
Etidronic acid (HEDP) is a diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
T8900 Seralutinib GB002 PDGFR
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.
T1210 Sodium etidronate Didronel Phosphatase
Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha...
T1613 Hydralazine hydrochloride Hydralazine HCl,Apresoline MAO , HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...
T2561 Macitentan ACT-064992 Apoptosis , Endothelin Receptor
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).
T14782 Brilaroxazine RP5063 Dopamine Receptor , 5-HT Receptor
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...
T5329 Trandolapril Angiotensin-converting Enzyme (ACE)
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.
T4454 Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,Trans-2-Dodecenedioic Acid Antioxidant
Traumatic Acid (Dodec-2-Enedioic Acid) is a product of the hydroperoxide lyase pathway in plants. Potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus.
T3034 Eprazinone dihydrochloride Resplen,Mucitux,Eftapan,NSC 317935,Eprazinone 2HCl Others , Neurokinin receptor
Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect.
T30615 Bupicomide
Bupicomide is a vasodilator that significantly reduces systolic, diastolic, and means arterial pressure, as well as peripheral vascular resistance.
T70793 Parogrelil Free Base
Parogrelil Free Base is a phosphodiesterase inhibitor, improves claudication-limited exercise performance in patients with peripheral arterial disease.
T11339L Furegrelate PPAR
FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.
T26841 BMS 182874 BMS182874,BMS-182874 Endothelin Receptor
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat ...
T34146 Propanidid FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol GABA Receptor
Propanidid (Sombrevin) is a gamma-aminobutyric acid type A receptor (GABAA) agonist and a fast-acting intravenous anesthetic that lowers arterial blood pressure.
T0163 Nisoldipine BAY-k 5552 Calcium Channel , Reactive Oxygen Species
Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
T0317 Buflomedil hydrochloride Buflomedil HCl,Fonzylane,Loftyl Adrenergic Receptor
Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.
T6147 Nortadalafil Demethyl Tadalafil PDE
Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.
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TargetMol