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Hydralazine hydrochloride

Catalog No. T1613 CAS 304-20-1

Synonyms: Hydralazine HCl, Apresoline

Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.

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Hydralazine hydrochloride Chemical Structure

Hydralazine hydrochloride, CAS 304-20-1

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50 mg	In stock	$ 33.00
100 mg	In stock	$ 47.00
200 mg	In stock	$ 58.00
500 mg	In stock	$ 92.00

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Purity: 99.86%

Purity: 99.1%

Biological Description

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Storage & Solubility Information

Description	Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.
In vitro	Hydralazine impairs up-regulation of RAG-2 gene expression and reduces secondary Ig gene rearrangements. Hydralazine subverts B lymphocyte tolerance to self and contributes to generation of pathogenic autoreactivity by disrupting receptor editing. [1] Hydralazine directly scavenges free acrolein, decreasing intracellular acrolein availability and thereby suppressing macromolecular adduction. Hydralazine inhibits cross-linking if adding 30 min after commencing acrolein exposure but is ineffective if added after a 90-min delay. [2] Hydralazine (0.1-10 mM) inhibits both extracellular and intracellular ROS production by inflammatory macrophages, by a ROS-scavenging mechanism probably affecting superoxide radical (O(2)(-))-generation by xanthine oxidase (XO) and nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase. Hydralazine (0.1-10 mM) significantly reduces NO() generation, and this effect is attributable to an inhibition of NOS-2 gene expression and protein synthesis. Hydralazine also effectively blocks COX-2 gene expression which perfectly correlated with a reduction of protein levels and PGE(2) synthesis. [3] Hydralazine protects against not only acrolein-mediated injury, but also compression in guinea pig spinal cord ex vivo. Hydralazine can significantly alleviate acrolein-induced superoxide production, glutathione depletion, mitochondrial dysfunction, loss of membrane integrity, and reduces compound action potential conduction. [4]
In vivo	Hydralazine affords strong, dose-dependent protection against the increases in plasma marker enzymes but not the hepatic glutathione depletion produced by allyl alcohol in mice. [5]

Synonyms	Hydralazine HCl, Apresoline
Molecular Weight	196.64
Formula	C8H9ClN4
CAS No.	304-20-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Mazari L, et al. Proc Natl Acad Sci U S A,2007, 104(15), 6317-6322. 2. Burcham PC, et al. Mol Pharmacol,2006, 69(3), 1056-1065. 3. Leiro JM, et al. Int Immunopharmacol,2004, 4(2), 163-177. 4. Hamann K, et al. J Neurochem,2008, 104(3), 708-718. 5. Kaminskas LM, et al. J Pharmacol Exp Ther,2004, 310(3), 12003-12010.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Approved Drug Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library Neuronal Signaling Compound Library Anti-Hypertension Compound Library

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Keywords

Hydralazine hydrochloride 304-20-1 Chromatin/Epigenetic Metabolism Neuroscience HIF/HIF Prolyl-Hydroxylase MAO HIFs Hydralazine Hydrochloride HIF-PH Hypoxia-inducible factors antihypertensive Hydralazine HCl Inhibitor inhibit orally active Apresoline arterial vessel Hydralazine inhibitor

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