antinociceptive — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7907	7-Methoxyflavone		Others
	7-Methoxyflavone isolated from Zornia brasiliensis with antinociceptive effects.		Others
T6554	JZL 184	JZL184	Lipase
	JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.		Lipase
T6S1010	Allomatrine		Others
	Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord.		Others
T23498	UNC3230	UNC 3230	Others
	UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230(UNC 3230) also inhibits PIP4K2C.		Others
T3834	8-Epideoxyloganic acid		ROS , Immunology/Inflammation related
	8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibl...		ROS , Immunology/Inflammation related
T7052	Gnetol		Tyrosinase , COX , HDAC , AChR
	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...		Tyrosinase , COX , HDAC , AChR
T3254	PHYTOL	trans-Phytol,(E)-Phytol	Antibacterial , PPAR , Parasite
	PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects....		Antibacterial , PPAR , Parasite
T6S1653	Albiflorin	Alibiflorin	Reactive Oxygen Species
	1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ...		Reactive Oxygen Species
T9461	AZ194		Sodium Channel
	CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.		Sodium Channel
T1191L	Metamizole sodium	Analgin,Dipyron	COX
	Metamizole sodium (Analgin) is a drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.		COX
T8014	Epoxylinalool	2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran	Others
	Epoxylinalool (2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran) is a naturally occurring monoterpene alcohol widely used in the production of perfumes and flavors.		Others
T22733	DL-AP5		NMDAR
	DL-AP5 is a NMDA antagonist.		NMDAR
T5S2360	Corydaline	Corydalin,(+)-Corydaline	P450 , Virus Protease , Opioid Receptor , AChE
	1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastr...		P450 , Virus Protease , Opioid Receptor , AChE
T0437	Inosine	INO 495,NSC 20262	ROS , Endogenous Metabolite , Adenosine Receptor
	Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.		ROS , Endogenous Metabolite , Adenosine Receptor
T5S1882	Songorine	Napellonine,Zongorine,Bullatine G	Others , GABA Receptor
	Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.		Others , GABA Receptor
T15781	LP-935509		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
	LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-...		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T5S1131	Ganoderic acid C6		Others
	1. Ganoderic acid C6 has antinociceptive activity.		Others
T6S0743	Sesamoside		Others
	Sesamoside has antinociceptive activity.		Others
TN2540	1-Hydroxybaccatin I		Others
	1-Hydroxybaccatin I possesses significant antinociceptive activity against p- benzoquinone-induced abdominal contractions.		Others