anti-prostate — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN7020	Astragenol		Others
	Astragenol is an intermediate for the synthesis of astragenel derivatives. Astragenol derivatives are promising anti-inflammatory drugs in prostate cancer research.		Others
T6400	AZD3514		Androgen Receptor
	AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.		Androgen Receptor
T0380	Bicalutamide	ICI-176334	Androgen Receptor , Autophagy
	Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.		Androgen Receptor , Autophagy
T3324	Lycorine	Galanthidine,Narcissine,Amarylline,Belamarine,Licorine	Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T2895	Lupeol	Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol	Apoptosis , Androgen Receptor , Akt
	Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.		Apoptosis , Androgen Receptor , Akt
T2S1158	4,5-Dicaffeoylquinic acid	3,4-Dicaffeoylquinic acid,Isochlorogenic acid C	Others , HBV , Endogenous Metabolite
	1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.		Others , HBV , Endogenous Metabolite
T2275	YK-4-279		Apoptosis , DNA/RNA Synthesis
	YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.		Apoptosis , DNA/RNA Synthesis
T4S1173	Agrimol B		Sirtuin , PPAR
	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.		Sirtuin , PPAR
T4102	Goserelin acetate	Fertilan,ICI-118630 acetate,Zoladex	Apoptosis , GNRH Receptor
	Goserelin acetate (Fertilan) is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.		Apoptosis , GNRH Receptor
T23647	Zindoxifene	D 16726	Estrogen/progestogen Receptor
	Zindoxifene (D 16726) is an anti-estrogenic compound with antitumor activity that can be used in studies of breast and prostate cancer.		Estrogen/progestogen Receptor
T6S1255	Ophiopogonin-D		ROS
	Ophiopogonin D(OPD) significantly inhibited the in vitro and in vivo growth of prostate cells via RIPK1, OPD may be developed as a potential anti-prostate cancer agent.		ROS
T4869	D-Allose	β-D-Allopyranose,D-(+)-ALLOSE	Others , Endogenous Metabolite
	D-Allose (β-D-Allopyranose) is a rare naturally occurring monosaccharide known to exert anti-proliferative effects on cancer cells. The effects of D-Allose on the cellular membranes of hormone-refractory prostate cancer ...		Others , Endogenous Metabolite
T14008	2,2,5,7,8-Pentamethyl-6-Chromanol	PMC	Androgen Receptor
	2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.		Androgen Receptor
T0740	Metformin hydrochloride	Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride	Mitophagy , AMPK , Autophagy
	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro...		Mitophagy , AMPK , Autophagy
T7990	9-hydroxy-4-androstene-3,17-dione		Others
	9-hydroxy-4-androstene-3,17-dione is a steroid hormone. It has anti-tumor activity and can inhibit the growth of many types of cancer cells, including breast, prostate and lung cancer cells.		Others
T0272	Nilutamide	RU23908	Androgen Receptor
	Nilutamide (RU23908), an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors, but not for estrogen, progesto...		Androgen Receptor
T4S2157	Campesterol	(24R)-5-Ergosten-3β-ol	Endogenous Metabolite
	Campesterol ((24R)-5-Ergosten-3β-ol) is a plant sterol with cholesterol lowering and anticarcinogenic effects, it and other plant sterols often decrease LDL cholesterol levels overall. Campesterol has anti-inflammatory e...		Endogenous Metabolite
TN1805	Isosilybin B		Apoptosis , Androgen Receptor
	Isosilybin B is a flavonolignan extracted from silymarin that exhibits anti-prostate cancer (PCA) activity, inhibits cancer cell proliferation, and contributes to G1-phase blockade and apoptosis.Isosilybin B induces degr...		Apoptosis , Androgen Receptor
T29110	VPC-13163	2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163	Others
	VPC-13163 (NSC-52361) has strong anti-proliferative activity against LNCaP and Enzalutamide-resistant prostate cancer cell lines (MR49F) whereas it did not affect the growth of AR independent PC3 cell line. It also inhib...		Others
TN1804	Isosilybin A		Apoptosis , Tyrosinase , PPAR , ABC
	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angio...		Apoptosis , Tyrosinase , PPAR , ABC