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Bicalutamide

Catalog No. T0380 CAS 90357-06-5

Synonyms: ICI-176334

Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.

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Bicalutamide, CAS 90357-06-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 32.00
100 mg	In stock	$ 45.00
200 mg	In stock	$ 53.00
500 mg	In stock	$ 68.00
1 g	In stock	$ 85.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.97%

Purity: 99.88%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
Targets&IC50	Androgen receptor:0.16 μM
In vivo	Single bicalutamide reduces tumor growth by 79%, at defined submaximal doses. The ridaforolimus-bicalutamide combination exhibits improved and potent antitumor activity, almost completely abrogating tumor growth. The combination is also well tolerated, as evidenced by no significant changes in body weight over the course of treatment. Plasma PSA levels are again tightly linked to tumor growth in the combination-treated mice. [3]
Kinase Assay	Whole-cell competitive binding assays: Whole-cell competitive binding assays are performed in LNCaP/AR(codon-switch) (LNCaP/AR(cs)) (harbors a mixture of exogenous wild-type AR and endogenous mutant AR (T877A)) and cells propagated in Iscove's or RPMI media supplemented with 10% fetal bovine serum, or during the assay with 10% charcoal-stripped, dextran-treated fetal bovine serum (CSS). Cells are pre-incubated with 18F-FDHT, increasing concentrations (1pM to 1 μM) of cold Bicalutamide are added, and the assay is performed to measure specific uptake of 18F-FDHT (4). IC50 values are determined using a one site binding model with least squares curve fitting and R2 > 0.99.
Cell Research	Exponentially growing C4-2 cells are plated into two 96-well plates and incubated overnight at 37 ?C. Twenty-four hours later one plate is aspirated and stored at -80 ?C and the other treated with 10-fold serial concentrations of ridaforolimus (1000 nM to 0.0001 nM) or vehicle (ethanol). Following 72 hours culture at 37 ?C, the plates are assessed simultaneously for cell growth using the Cy qUANT Cell Proliferation Assay kit. Bicalutamide and Ridaforolimus combination proliferation assays are performed similarly except cell growth is determined as the change in cell number between vehicle control and compound treated cells after 72 hours in culture.(Only for Reference)

Synonyms	ICI-176334
Molecular Weight	430.37
Formula	C18H14F4N2O4S
CAS No.	90357-06-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 43 mg/mL (100 mM)

Ethanol: 4.3 mg/mL (10 mM)

References and Literature

1. Clegg NJ, et al. Cancer Res. 2012, 72(6), 1494-1503. 2. Colquhoun AJ, et al. Prostate Cancer Prostatic Dis. 2012. 3. Squillace RM, et al. Int J Oncol. 2012.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library NO PAINS Compound Library Autophagy Compound Library Pediatric Drug Library FDA-Approved & Pharmacopeia Drug Library

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BMS-564929 CTK8A3536 AR antagonist 1 Nandrolone propionate Androgen receptor degrader-2 Enzalutamide Sunset Yellow FCF YXG-158

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Keywords

Bicalutamide 90357-06-5 Autophagy Endocrinology/Hormones Androgen Receptor cancer androgen castration-resistant ICI 176334 receptor prostate cancer Inhibitor prostate ICI-176334 inhibit ICI176334 anti-androgen non-steroidal inhibitor

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