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Isosilybin A

Catalog No. TN1804   CAS 142796-21-2

Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.

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Isosilybin A Chemical Structure
Isosilybin A, CAS 142796-21-2
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1 mg In stock $ 80.00
5 mg In stock $ 198.00
10 mg In stock $ 297.00
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1 mL * 10 mM (in DMSO) In stock $ 218.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angiogenic efficacy, it has anti-prostate cancer (PCA) activity that is mediated via cell cycle arrest and apoptosis induction.
In vitro To investigate the effects of milk thistle extract and its main flavonolignans (silybin A, silybin B, Isosilybin A and isosilybin B) on CYP2C8 activity at relevant concentrations, the effect of milk thistle extract and the flavonolignans on CYP2C8 enzyme activity was studied in vitro using human liver microsomes (HLM) incorporating an enzyme-selective substrate for CYP2C8, amodiaquine. Metabolite formation was analyzed using liquid chromatography-tandem mass spectrometry (LC/MS-MS). The concentration causing 50% inhibition of enzyme activity (IC50) was used to express the degree of inhibition. Isosilibinin, a mixture of the diastereoisomers Isosilybin A and isosilybin B, was found to be the most potent inhibitor, followed by isosilybin B with IC50 values (mean ± SE) of 1.64 ± 0.66 μg/mL and 2.67 ± 1.18 μg/mL, respectively. The rank order of observed inhibitory potency after isosilibinin was silibinin > Isosilybin A > silybin A > milk thistle extract > and silybin B[1]
Source
Molecular Weight 482.44
Formula C25H22O10
CAS No. 142796-21-2

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90mg/ml(186.55mM), sonification is recommended.

TargetMolReferences and Literature

1. The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.Chem Biol Interact. 2017 Jun 1;271:24-29.

Related compound libraries

This product is contained In the following compound libraries:
Flavonoid Natural Product Library Rare Natural Compound Library

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Keywords

Isosilybin A 142796-21-2 Apoptosis DNA Damage/DNA Repair Membrane transporter/Ion channel Metabolism Proteases/Proteasome Tyrosinase PPAR ABC inhibit Inhibitor inhibitor

 

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