yap — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2160L1	YAP-TEAD-IN-1 acetate	YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)	YAP
	YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.		YAP
T60218	YAP/TAZ inhibitor-2		YAP
	YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor activity [1].		YAP
TP2160	YAP-TEAD-IN-1		Others
	YAP-TEAD-IN-1 is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
T13364	YAP/TAZ inhibitor-1		ROCK
	YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).		ROCK
TP2160L	YAP-TEAD-IN-1 TFA		Others
	YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
T72888	YAP-TEAD-IN-2		YAP
	YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50) value of 2.7 nM [1].		YAP
T77725	YAP-TEAD-IN-3	IAG933	YAP
	YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 ...		YAP
T8421	TED-347		YAP
	TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.		YAP
T9053	Lats-IN-1		Others , YAP
	Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.		Others , YAP
T22372	MYF-01-37	1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others , YAP
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.		Others , YAP
T9954	K-975		Others
	K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.		Others
T3112	Verteporfin	BPD-MA,CL 318952	Apoptosis , YAP , VDA , Autophagy
	Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.		Apoptosis , YAP , VDA , Autophagy
T3050	ML-7 hydrochloride	ML-7 HCl	Serine/threonin kinase , Myosin , YAP , PKA , PKC
	ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and...		Serine/threonin kinase , Myosin , YAP , PKA , PKC
T1477	AICAR	NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)	Mitophagy , YAP , AMPK , Autophagy
	AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.		Mitophagy , YAP , AMPK , Autophagy
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T7038	4-Methylayapin	4-METHYL-6,7-METHYLENEDIOXYCOUMARIN	Others
	4-Methylayapin is a useful organic compound for research related to life sciences. The catalog number is T7038 and the CAS number is 15071-04-2.		Others
TN1489	3'-Methoxyapiin	Graveobioside B,3'-Methoxy apiin,Chrysoeriol 7-apiosylglucoside	Others
	3'-Methoxyapiin (Graveobioside B) is a flavonoid from the herbs of Eminium spiculatum.		Others
TN2353	8-Hydroxyapigenin	Isoscutellarein	Antioxidant , Influenza Virus
	8-Hydroxyapigenin (Isoscutellarein) is a brassinaceous compound derived from the plant Scutellaria baicalensis with anti-inflammatory, antioxidant and anti-influenza virus activity.		Antioxidant , Influenza Virus
TN2422	6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide		Others
	6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide is a natural product from Carthamus tinctorius Linn.		Others
T79933	(−)-N-Hydroxyapiosporamide	NHAP	NF-κB
	(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has potential applications in colorectal cancer (CRC) research [1...		NF-κB