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AICAR

Catalog No. T1477 CAS 2627-69-2

Synonyms: NSC105823, AICA Riboside, Acadesine, AICAR (Acadesine)

AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AICAR, CAS 2627-69-2

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 42.00
100 mg	In stock	$ 65.00
200 mg	In stock	$ 98.00
500 mg	In stock	$ 229.00
1 g	In stock	$ 339.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.71%

Purity: 99.19%

Purity: 98.21%

Purity: 98.00%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

Cell Research

Acadesine is added to K562 cell lines or primary cells (103 CD34+ cells/mL) growing in semisolid methyl cellulose medium. MethoCult H4100 or H4236 are used for cell lines and primary CD34+ cells respectively. Colonies are detected after 10 days of culture by adding 1 mg/mL of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reagent and are scored by Image J quantification software. (Only for Reference)

Synonyms	NSC105823, AICA Riboside, Acadesine, AICAR (Acadesine)
Molecular Weight	258.23
Formula	C9H14N4O5
CAS No.	2627-69-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 19.4 mg/mL (75 mM)

DMSO: 19.4 mg/mL (75 mM)

References and Literature

1. Corton JM, et al. Eur J Biochem, 1995, 229(2), 558-565. 2. Campàs C, et al. Blood, 2003, 101(9), 3674-368 3. Robert G, et al. PLoS One, 2009, 4(11), e7889. 4. Fabian TC, et al. Surgery, 1996, 119(3), 302-315. 5. Mathew JP, et al. J Thorac Cardiovasc Surg, 1995, 109(3), 448-456. 6. Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage[J]. 2020, 11(1): 1-22. 7. Shang Z, Zhang T, Jiang M, et al. High-carbohydrate, High-fat Diet-induced Hyperlipidemia Hampers the Differentiation Balance of Bone Marrow Mesenchymal Stem Cells by Suppressing Autophagy via the AMPK/mTOR Pathway in Rat Models[J]. 2020.

Citations

1. Rao X S, Cong X X, Gao X K, et al. AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake. Cell Death & Differentiation. 2021: 1-21. 2. Qiu W Q, Ai W, Zhu F D, et al. Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Free Radical Biology and Medicine. 2022, 179: 76-94. 3. Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage. Stem Cell Research & Therapy. 2020, 11(1): 1-22 4. Liang X, Liang J, Zhang S, et al.Di-2-ethylhexyl phthalate disrupts hepatic lipid metabolism in obese mice by activating the LXR/SREBP-1c and PPAR-α signaling pathways.Science of The Total Environment.2024: 169919.

Related compound libraries

This product is contained In the following compound libraries：

FDA-Approved Kinase Inhibitor Library Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Compound Library NO PAINS Compound Library Cancer Cell Differentiation Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AICAR 2627-69-2 Autophagy Chromatin/Epigenetic PI3K/Akt/mTOR signaling Stem Cells Mitophagy YAP AMPK Yes-associated protein inhibit NSC105823 NSC-105823 Endogenous Metabolite NSC 105823 AMP-activated protein kinase AICA Riboside Acadesine Mitochondrial Autophagy AICAR (Acadesine) Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.