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AICAR

Catalog No. T1477   CAS 2627-69-2
Synonyms: NSC105823, AICA Riboside, Acadesine, AICAR (Acadesine)

AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.

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AICAR Chemical Structure
AICAR, CAS 2627-69-2
Pack Size Availability Price/USD Quantity
25 mg In stock $ 30.00
50 mg In stock $ 42.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.71%
Purity: 99.19%
Purity: 98.21%
Purity: 98.00%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
Cell Research Acadesine is added to K562 cell lines or primary cells (103 CD34+ cells/mL) growing in semisolid methyl cellulose medium. MethoCult H4100 or H4236 are used for cell lines and primary CD34+ cells respectively. Colonies are detected after 10 days of culture by adding 1 mg/mL of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reagent and are scored by Image J quantification software. (Only for Reference)
Synonyms NSC105823, AICA Riboside, Acadesine, AICAR (Acadesine)
Molecular Weight 258.23
Formula C9H14N4O5
CAS No. 2627-69-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 19.4 mg/mL (75 mM)

DMSO: 19.4 mg/mL (75 mM)

TargetMolReferences and Literature

1. Corton JM, et al. Eur J Biochem, 1995, 229(2), 558-565. 2. Campàs C, et al. Blood, 2003, 101(9), 3674-368 3. Robert G, et al. PLoS One, 2009, 4(11), e7889. 4. Fabian TC, et al. Surgery, 1996, 119(3), 302-315. 5. Mathew JP, et al. J Thorac Cardiovasc Surg, 1995, 109(3), 448-456. 6. Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage[J]. 2020, 11(1): 1-22. 7. Shang Z, Zhang T, Jiang M, et al. High-carbohydrate, High-fat Diet-induced Hyperlipidemia Hampers the Differentiation Balance of Bone Marrow Mesenchymal Stem Cells by Suppressing Autophagy via the AMPK/mTOR Pathway in Rat Models[J]. 2020.

TargetMolCitations

1. Rao X S, Cong X X, Gao X K, et al. AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake. Cell Death & Differentiation. 2021: 1-21. 2. Qiu W Q, Ai W, Zhu F D, et al. Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Free Radical Biology and Medicine. 2022, 179: 76-94. 3. Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage. Stem Cell Research & Therapy. 2020, 11(1): 1-22 4. Liang X, Liang J, Zhang S, et al.Di-2-ethylhexyl phthalate disrupts hepatic lipid metabolism in obese mice by activating the LXR/SREBP-1c and PPAR-α signaling pathways.Science of The Total Environment.2024: 169919.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Target-Focused Phenotypic Screening Library

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Keywords

AICAR 2627-69-2 Autophagy Chromatin/Epigenetic PI3K/Akt/mTOR signaling Stem Cells Mitophagy YAP AMPK Yes-associated protein inhibit NSC105823 NSC-105823 Endogenous Metabolite NSC 105823 AMP-activated protein kinase AICA Riboside Acadesine Mitochondrial Autophagy AICAR (Acadesine) Inhibitor inhibitor

 

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