Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Verteporfin, a benzoporphyrin derivative monoacid ring A, can inhibit the activity of YAP.
Description | Verteporfin, a benzoporphyrin derivative monoacid ring A, can inhibit the activity of YAP. |
Kinase Assay | Cells (5 × 103) are plated in 96 well plates. Cells are treated the next day for 24 to 48 hours and then assessed for caspase-3 activity by Caspase-Glo-3/7 Assay, as per manufacturer's instructions and a luminescence plate reader. |
Cell Research | Verteporfin is dissolved in DMSO. PDX cells co-cultured with S17 cells are treated with 16 combinations of verteporfin (60 nM, 120 nM, 180 nM, and 240 nM) and dasatinib (12 nM, 24 nM, 36 nM, and 48 nM). The viabilities of cells treated with each combination are measured after 48 h using FACS Aria flow cytometer. In order to estimate drug interaction between verteporfin and dasatinib, a normalized isobologram and fraction affectedcombination index (CI) plot are made using CompuSyn software. CI values greater than 1.0 indicated antagonistic effects, equal to 1.0 additive effects, and below 1.0 synergistic effects. |
Synonyms | BPD-MA, CL 318952, 维替泊芬 |
Molecular Weight | 1437.614 |
Formula | C82H84N8O16 |
CAS No. | 129497-78-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: <1 mg/mL
DMSO: 93 mg/mL (129.4 mM)
H2O: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Verteporfin 129497-78-5 凋亡 干细胞 血管生成 自噬 Apoptosis Autophagy VDA YAP inhibit CL318952 CL-318952 Yes-associated protein CL 318952 BPD-MA Inhibitor inhibitor