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Verteporfin

Catalog No. T3112 CAS 129497-78-5

Synonyms: BPD-MA, CL 318952, 维替泊芬

Verteporfin, a benzoporphyrin derivative monoacid ring A, can inhibit the activity of YAP.

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Verteporfin, CAS 129497-78-5

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Verteporfin, a benzoporphyrin derivative monoacid ring A, can inhibit the activity of YAP.
Kinase Assay	Cells (5 × 103) are plated in 96 well plates. Cells are treated the next day for 24 to 48 hours and then assessed for caspase-3 activity by Caspase-Glo-3/7 Assay, as per manufacturer's instructions and a luminescence plate reader.
Cell Research	Verteporfin is dissolved in DMSO. PDX cells co-cultured with S17 cells are treated with 16 combinations of verteporfin (60 nM, 120 nM, 180 nM, and 240 nM) and dasatinib (12 nM, 24 nM, 36 nM, and 48 nM). The viabilities of cells treated with each combination are measured after 48 h using FACS Aria flow cytometer. In order to estimate drug interaction between verteporfin and dasatinib, a normalized isobologram and fraction affectedcombination index (CI) plot are made using CompuSyn software. CI values greater than 1.0 indicated antagonistic effects, equal to 1.0 additive effects, and below 1.0 synergistic effects.

Synonyms	BPD-MA, CL 318952, 维替泊芬
Molecular Weight	1437.614
Formula	C82H84N8O16
CAS No.	129497-78-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

DMSO: 93 mg/mL (129.4 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Schmidt-Erfurth U, et al. Surv Ophthalmol, 2000, 45(3), 195-214. 2. Granville DJ, et al. Blood, 2000, 95(1), 256-262. 3. Liu-Chittenden Y, et al. Genes Dev. 2012, 26(12):1300-5. 4. Isfort I, Elges S, Cyra M, et al. Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone[J]. Scientific Reports. 2019, 9(1): 1-9. 5. Zhuang Q, Li F, Liu J, et al. Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis[J]. Laboratory Investigation. 2021, 101(2): 258-270. 6. Ilka Isfort, Magdalene Cyra, Sandra Elges, Sareetha Kailayangiri, Bianca Altvater, Claudia Rossig, Konrad Steinestel et al. SS18-SSX-dependent YAP/TAZ Signaling in Synovial Sarcoma [J]. Clinical Cancer Research. 2019 Feb 27: clincanres-3553. 7. Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki et al. Requirement for YAP1 signaling in myxoid liposarcoma [J]. EMBO molecular medicine. 2019 May;11(5): e9889. 8. Tang Y, Fang G, Guo F, et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer[J]. Cancer Cell. 2020, 38(1): 115-128. e9. 9. Peng G, Suo S, Cui G, et al. Molecular architecture of lineage allocation and tissue organization in early mouse embryo[J]. Nature. 2019, 572(7770): 528-532.

Citations

1. Peng G, Suo S, Cui G, et al. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature. 2019, 572(7770): 528-532. 2. Tang Y, Fang G, Guo F, et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020, 38(1): 115-128. e9. 3. Isfort I, Cyra M, Elges S, et al. SS18-SSX-dependent YAP/TAZ Signaling in Synovial Sarcoma. Clinical Cancer Research. 2019, 25(12): 3718-3731 4. Trautmann M, Cheng Y Y, Jensen P, et al. Requirement for YAP1 signaling in myxoid liposarcoma. EMBO Molecular Medicine. 2019, 11(5): e9889 5. Zhuang Q, Li F, Liu J, et al. Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis. Laboratory Investigation. 2021, 101(2): 258-270. 6. Isfort I, Elges S, Cyra M, et al. Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Scientific Reports. 2019, 9(1): 1-9

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Inhibitor Library Macrocyclic Compound Library Wnt/Hedgehog/Notch Compound Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library Anti-COVID-19 Compound Library

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Keywords

Verteporfin 129497-78-5 凋亡干细胞血管生成自噬 Apoptosis Autophagy VDA YAP inhibit CL318952 CL-318952 Yes-associated protein CL 318952 BPD-MA Inhibitor inhibitor

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