sorafenib — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0093L	Sorafenib	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T16909	Sorafenib-d3	Sorafenib (D3),Bay 43-9006 (D3)	Raf , VEGFR
	Sorafenib-d3 (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively).		Raf , VEGFR
T0093	Sorafenib tosylate	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T12976	Sorafenib-d4	Sorafenib (D4),Bay 43-9006 (D4)	Others
	Sorafenib D4 is the deuterium labeled Sorafenib. Sorafenib is an inhibitor of multikinase (Raf-1, B-Raf, and VEGFR-3 IC50s of 6 nM, 20 nM, and 22 nM, respectively).		Others
T36681	Sorafenib N-oxide
	Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd =...
T1792	Regorafenib	BAY 73-4506,Fluoro-Sorafenib	Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T30301	BAY-721973	Sorafenib metabolite M3,UNII-83F1Z938Q0,BAY 721973
	BAY-721973 is a bio-active chemical.
T9698	UC2288		Mdm2 , p53
	UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.		Mdm2 , p53
T13410	ZLDI-8		Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related
	ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T22424	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea		Apoptosis , STAT
	SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular ca...		Apoptosis , STAT
T77440	Codrituzumab	RG-7686,RO5137382,GC33
	Codrituzumab (GC3) is a humanized antibody against the glypican-3 hepatocellular carcinoma protein that can be used in combination with sorafenib to study incurable advanced hepatocellular carcinoma (HCC).
T14997	Conteltinib	SY-707,CT-707	FAK , PYK2 , ALK
	Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hypoxia-mediated sorafenib resistance in hepatocellular carci...		FAK , PYK2 , ALK
T7897	PK150		Others , Antibacterial
	PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations.		Others , Antibacterial
T8478	SC-43		Apoptosis , Phosphatase , STAT
	SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.		Apoptosis , Phosphatase , STAT
T79407	HL23		Others
	HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC). It promotes acetylation at the TXNIP promoter and increases TXNIP expression, which in turn modulates potassium chan...		Others
T28697	SC-2001	SC2001
	SC-2001 is a MCL-1 inhibitor. SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. SC-2001 overcomes STAT3-mediated sorafenib resistance through RF...
T71783	Oxythiamine chloride HCl
	Oxythiamine chloride HCl is a thiamine antimetabolite that has anticancer activities. It is converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate, a transketolase inhibitor. Oxythiamine decreases transketo...
T36882	CAY10773
	CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HC...