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SC-43

Catalog No. T8478   CAS 1400989-25-4

SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.

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SC-43 Chemical Structure
SC-43, CAS 1400989-25-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 96.00
5 mg In stock $ 197.00
10 mg In stock $ 289.00
25 mg In stock $ 537.00
50 mg In stock $ 768.00
100 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 226.00
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Purity: 99.26%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.
In vitro SC-43, a sorafenib derivative.SC-43-induced apoptosis in cholangiocarcinoma (CCA) via a novel mechanism.?Three CCA cell lines (HuCCT-1, KKU-100 and CGCCA) were treated with SC-43 to determine their sensitivity to SC-43-induced cell death and apoptosis.?SC-43 activated SH2 domain-containing phosphatase 1 (SHP-1) activity, leading to p-STAT3 and downstream cyclin B1 and Cdc2 downregulation, which induced G2-M arrest and apoptotic cell death.?Importantly, SC-43 augmented SHP-1 activity by direct binding to N-SH2 and relief of its autoinhibition.?Deletion of the N-SH2 domain (dN1) or point mutation (D61A) of SHP-1 counteracted the effect of SC-43-induced SHP-1 phosphatase activation and antiproliferation ability in CCA cells[1].
In vivo In vivo assay revealed that SC-43 exhibited xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation[1].
Molecular Weight 431.8
Formula C21H13ClF3N3O2
CAS No. 1400989-25-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (231.59 mM), sonification is recommended.

TargetMolReferences and Literature

1. Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma. Oncotarget. 2017 May 10;8(39):65077-65089. 2. Tung-Hung Su, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017 May 11;7(1):1728.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Lung Cancer Compound Library NO PAINS Compound Library Lipid Metabolism Compound Library Transcription Factor-Targeted Compound Library Covalent Inhibitor Library Glycometabolism Compound Library Anti-Breast Cancer Compound Library

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Keywords

SC-43 1400989-25-4 Apoptosis JAK/STAT signaling Metabolism Stem Cells Phosphatase STAT antiproliferative Inhibitor SHP-1 PTPN6 SC43 caspase-3 anti-fibrotic p-STAT3 anticancer orally PARP SC 43 inhibit inhibitor

 

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