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Metabolism Phosphatase SC-43

SC-43

Catalog No. T8478   CAS 1400989-25-4

SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.

SC-43, CAS 1400989-25-4
Pack Size Availability Price/USD Quantity
1 mg In stock 130.00
5 mg In stock 263.00
10 mg In stock 395.00
25 mg In stock 710.00
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Purity 99.26%
Biological Description
Chemical Properties
Storage & Solubility Information
Description SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and anticancer effects.
Targets&IC50 SHP-1 ,   STAT3 ,   apoptosis
In vivo In vivo assay revealed that SC-43 exhibited xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation[1].
Molecular Weight 431.8
Formula C21H13ClF3N3O2
CAS No. 1400989-25-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Ming-Hung Hu, et al. Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma. Oncotarget. 2017 May 10;8(39):65077-65089. 2. Tung-Hung Su, et al. Src-homology protein tyrosine phosphatase-1 agonist, SC-43, reduces liver fibrosis. Sci Rep. 2017 May 11;7(1):1728.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-cancer Compound Library Clinical Compound Library Stem cell Differentiation Compound Library Apoptosis Compound Library Immunology/Inflammation Compound Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-cancer Metabolism Compound Library Preclinical Compound Library JAK STAT Compound Library Phosphatase Inhibitor Library Anti-cancer Active Compound library Anti-cancer Drug library Drug Repurposing Library Small Molecule Immuno-Oncology Compound Library Lipid Metabolism Compound Library Glycometabolism Compound Library Anti-Pancreatic Cancer Compound Library

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