sarcoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38514	PMEDAP		Others , HIV Protease
	PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP also has anti-murine cytomega...		Others , HIV Protease
T13166	TK216		Others , DNA/RNA Synthesis
	TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.		Others , DNA/RNA Synthesis
T4527	Seclidemstat	SP-2577	Histone Demethylase
	Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.		Histone Demethylase
T2465	PF-562271	PF562271,PF 562271	FAK , PYK2 , CDK
	PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).		FAK , PYK2 , CDK
T21768	PF-562271 hydrochloride	PF-562271 HCl	FAK , PYK2 , CDK
	PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr...		FAK , PYK2 , CDK
T70841	Osteosarcoma-IN-D14
	Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes.
TN3548	Bulleyanin		Others
	Bulleyanin shows strong inhibition of mouse ehrlich ascites carcinoma (ECA), mouse sarcoma S-180, and mouse liver ascites.		Others
T73425	CFT8634
	CFT8634 is a degrader targeting BRD9. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors.
T1788	Tazemetostat	E-7438,EPZ6438	Histone Methyltransferase
	Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epith...		Histone Methyltransferase
T4349	Sitravatinib	MG516,MGCD516	Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor
	Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
T4350	Palifosfamide	ZIO-201,Isophosphamide mustard,Isophosphoramide mustard	DNA Alkylator/Crosslinker , DNA Alkylation , Drug Metabolite
	Palifosfamide (Isophosphamide mustard) lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to 6.75 μM for most cell lines excep...
T17155	Trabectedin	Ecteinascidin 743,ET-743	Apoptosis , Reactive Oxygen Species
	Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research. Trabectedin inhibits cell growth of MX-1, MCF7 and MCF7/DXR cells with IC50 values of 0...		Apoptosis , Reactive Oxygen Species
T35480	DBRD9-A	dBRD9-A
	Potent BRD9 degrader. Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xeno...
T19771	SXT1596	NSC-65667,SXT-1596,NSC 65667,SXT 1596,NSC65667
	SXT1596 is a novel SS18-SSX/TLE1 interaction inhibitor. SXT1596 reduces cell viability and reactivates EGR1 expression in synovial sarcoma.
T24709	RETRA
	RETRA is an agent of anticancer that acts by exerting anticancer activity in Ewing's sarcoma cells independent of their TP53 status.
T70230	FPTI
	FPTI is an inhibitor against SYT-SSX1 fusion protein in synovial sarcoma which down-regulates SYT-SSX1 and modulates its downstream target genes.
TN4455	Lucialdehyde B		Integrase , HSV
	Lucialdehyde B exhibits potent inhibitory activity against herpes simplex virus. It shows cytotoxic effects on Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines.		Integrase , HSV
T69283	Amikhellin HCl
	Amikhellin HCl, an antimitotic drug, is a synthetic water-soluble derivative of khellin, an alkaloid extracted from seeds of Ammi Visnaga. Amikhellin has been used so far mostly as a vasodiator. Amikhellin binds to doubl...
TN4457	Lucidal		Others
	Lucialdehyde C (Lucidal) exhibits potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED(50) values of 10.7, 4.7, 7.1, and 3.8 microg/ml, respectively.		Others
T1120L2	Dacarbazine citrate	DTIC citrate
	Dacarbazine citrate is an alkylating agent used to treat cancers of the lymphatic system and malignant melanoma (a type of skin cancer) in patients with certain conditions: islet cell carcinoma (part of the pancreas) Sof...