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PF-562271 hydrochloride

Catalog No. T21768 CAS 939791-41-0

Synonyms: PF-562271 HCl

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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PF-562271 hydrochloride, CAS 939791-41-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Targets&IC50	FAK:1.5 nM

Synonyms	PF-562271 HCl
Molecular Weight	543.95
Formula	C21H20F3N7O3S HCl
CAS No.	939791-41-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 91 mg/mL(167.3 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Roberts WG, et al. Cancer Res, 2008, 68(6), 1935-1944. 2. Lim ST, et al. Cell Cycle, 2008, 7(15), 2306-2314.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PF-562271 hydrochloride 939791-41-0 蛋白酪氨酸激酶细胞骨架细胞周期血管生成 CDK FAK PYK2 Proline-rich tyrosine kinase 2 Ewing inhibit Antitumor PF-562271 HCl PF-562271 Focal adhesion kinase Sarcoma VS-6062(hydrochloride) PTK2 protein tyrosine kinase 2 Pyk2 PF562271 hydrochloride PTK2 PF 562271 PF562271 Cancer PF 562271 hydrochloride Inhibitor Breast inhibitor

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