raw264.7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T41302	Itaconate-alkyne	ITalk	Others
	Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of itaconate in inflammatory macrophages and enables biochemical evaluation and proteomic analysis of its dire...		Others
T27730	KGP94	KGP-94,KGP 94	Cysteine Protease
	KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).		Cysteine Protease
T1031	Cloxacillin sodium monohydrate	Cloxacillin Sodium,Bactopen	Antibacterial , Antibiotic
	Cloxacillin sodium monohydrate (Cloxacillin Sodium) is the sodium salt of cloxaclliin, a semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity.		Antibacterial , Antibiotic
TN1109	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid	NOS , NO Synthase , Prostaglandin Receptor
	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.		NOS , NO Synthase , Prostaglandin Receptor
TN6750	2-tert-Butyl-1,4-benzoquinone		Nrf2
	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.		Nrf2
T5727	CAFESTOL		ERK , NF-κB , COX , PGE Synthase
	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production...		ERK , NF-κB , COX , PGE Synthase
TN2167	Rutaevin		Reactive Oxygen Species , NO Synthase
	Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.		Reactive Oxygen Species , NO Synthase
TP1938L	RS09 2TFA (1449566-36-2 free base)	RS09 2TFA 1449566-36-2(free base)	TLR
	RS09 2TFA (1449566-36-2 free base) is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 sp...		TLR
T6S1543	Dehydrodiisoeugenol		Others , NF-κB , COX , Antibacterial
	1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ...		Others , NF-κB , COX , Antibacterial
T3927	Phellopterin		GABA Receptor
	Phellopterin is a partial agonist of the central benzodiazepine receptors in vitro. Phellopterin shows a cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM. Phellopterin reduce TNF-alpha-induced VCA...		GABA Receptor
T5S0581	Sec-O-Glucosylhamaudol	Hamaudol 3-glucoside	Others , Opioid Receptor
	Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudo...		Others , Opioid Receptor
T6S0139	Neobavaisoflavone		Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...		Apoptosis , DNA/RNA Synthesis
T3929	Kaurenoic acid	Kauren-19-Oic Acid,kaurenoate,kaur-16-en-18-oic acid	Others
	Kaurenoic acid (kaurenoate) has anti-inflammatory potential in acetic acid-induced colitis, decreases in MDA level. Kaurenoic acid exerts a uterine relaxant effect acting principally through calcium blockade and in part,...		Others
TN1712	Gossypin		NF-κB , S6 Kinase
	Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i...		NF-κB , S6 Kinase
T2S1907	Coniferaldehyde	Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,Coniferyl aldehyde	Apoptosis , Antioxidant
	Coniferaldehyde (Ferulaldehyde) is a member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as an antifungal agent and ...		Apoptosis , Antioxidant
T4S1615	Sanggenon C	Sanggenone C	NF-κB
	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO pro...		NF-κB
T25356	E17110	E-17110,E 17110
	E17110 is an LXRβ agonist. E17110 exhibited a significant activation effect on LXRβ (EC50: 0.72 μmol/L). E17110 also increased the expression of ABCA1 and ABCG1 in RAW264.7 macrophages. E17110 significantly decreased cel...
TN4633	Neocryptotanshinone II		NOS , NF-κB
	Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-ÎºB and iNOS signaling pathways.		NOS , NF-κB
T72578	Siegesbeckialide I
	Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.
T82229	HD-2a
	HA-2a inhibits the JAK2/STAT3 pathway by downregulating circDcbld2 expression in RAW264.7 cells [1].