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3-O-Acetyl-16α-hydroxydehydrotrametenolic acid

Catalog No. TN1109 CAS 168293-14-9

Synonyms: 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7 cells.

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3-O-Acetyl-16α-hydroxydehydrotrametenolic acid Chemical Structure

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, CAS 168293-14-9

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Description

In vitro

Based on bioassay-guided fractionation using lipopolysaccharide (LPS)-stimulated Raw264.7 cells, chemical investigation of the EtOH extract of the sclerotia of P. cocos resulted in the isolation and identification of eight compounds including six triterpenoids, namely poricoic acid A (1), 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid(2), polyporenic acid C (3), 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid (4), trametenolic acid (5), and dehydroeburicoic acid (6), as well as (-)-pinoresinol (7) and protocatechualdehyde (8). The structures of the isolated compounds were determined by spectroscopic analysis, including 1H and 13C NMR spectra, and LC/MS analysis. The anti-inflammatory activities of the isolates were evaluated by estimating their effect on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated Raw264.7 as well as on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Compounds 1-5 inhibited NO production and iNOS expression in LPS-stimulated Raw264.7 cells. Among them, compound 1 exerted the highest anti-inhibitory activity and reduced PGE2 levels via downregulation of COX-2 protein expression.

Synonyms	3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid
Molecular Weight	512.72
Formula	C32H48O5
CAS No.	168293-14-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells.Bioorg Chem. 2017 Feb;70:94-99.

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Keywords

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9 GPCR/G Protein Immunology/Inflammation NOS NO Synthase Prostaglandin Receptor 3-O-Acetyl-16a-hydroxydehydrotrametenolic acid triterpenoid iNOS production 3-O-Acetyl-16 a-hydroxydehydrotrametenolic acid inhibit Nitric oxide synthases 3-O-Acetyl-16 α-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid Inhibitor Raw264.7 anti-inflammatory 3OAcetyl16αhydroxydehydrotrametenolic acid 3 O Acetyl 16α hydroxydehydrotrametenolic acid inhibitor

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