nmda-in-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12234	NMDA-IN-1		NMDAR
	NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).		NMDAR
T4752	1-Aminocyclopropane-1-carboxylic acid	1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite , NMDAR
	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...		Endogenous Metabolite , NMDAR
T60612	Neboglamine hydrochloride
	Neboglamine (CR-2249, XY-2401) hydrochloride is a positive modulator of NMDA receptor glycine site with orally active that can be used in the research of schizophrenia [1].
TP1179L	Porcine dynorphin A(1-13) acetate	Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base)	Opioid Receptor
	Porcine dynorphin A(1-13) acetate (Dynorphin A Porcine Fragment 1-13 acetate) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Exposure to dynorphin A (1-13) cause...		Opioid Receptor
T1751	Eliprodil	SL-820715	NMDAR , iGluR
	Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Pa...		NMDAR , iGluR
T6S0659	Rhynchophylline	Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel , NF-κB
	1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c...		Calcium Channel , NF-κB
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
T3486	3-MATIDA		GluR , NMDAR
	3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3...		GluR , NMDAR
T2768	Saikosaponin A		NF-κB , Antibacterial , Liver X Receptor
	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...		NF-κB , Antibacterial , Liver X Receptor
T6S1418	Praeruptorin C		Antioxidant , Calcium Channel
	1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...		Antioxidant , Calcium Channel
T1589	D-Cycloserine	RO-1-9213	Others , Antibacterial , Antibiotic , iGluR
	D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with other antituberculosis agents.		Others , Antibacterial , Antibiotic , iGluR
T0825	Ebselen	SPI-1005,PZ-51,CCG-39161	Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease
	Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b...
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
T2S2264	Linalool	Linalol,(±)-Linalool,Phantol	Apoptosis , IL Receptor , TNF , Endogenous Metabolite , iGluR
	1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury th...
T60513	NMDA-IN-2
	NMDA-IN-2 (compound 6b) is a Procaine derivative that is an inhibitor of NMDA receptor 2B subtype [1].
T61470	NMDA receptor antagonist 5
	NMDA receptor antagonist 5 (Compound 10e), a potent and non-toxic NMDA receptor antagonist, exhibits brain permeability. It is of significance in studying neurological disorders [1].
T60685	NMDA receptor modulator 3
	NMDA receptor modulator 3 (Compound 99) is a potent modulator of NMDA receptor that can be used in the research of neurological disorder [1].
T22734	DL-AP7		Others
	DL-AP7, a competitive NMDA antagonist and anticonvulsant, blocks NMDA-induced convulsions and impairs learning performance in mice during a passive avoidance task [1].		Others
T60695	DPQ
	DPQ is a potent inhibitor of PARP-1 that can be used in neuroprotection research. DPQ reduce the PARP activation induced by N-methyl-d-aspartate (NMDA), restoring ATP to near control levels as well as significantly atten...
T60306	NMDA receptor antagonist 4
	NMDA receptor antagonist 4 (IIc) is an uncompetitive, voltage-dependent, orally active NMDAR blocker, with an IC 50 of 1.93 μM. NMDA receptor antagonist 4 shows a positive predicted blood-brain-barrier (BBB) permeability...