Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 42.00 | |
10 mg | In stock | $ 58.00 | |
25 mg | In stock | $ 86.00 | |
50 mg | In stock | $ 115.00 | |
100 mg | In stock | $ 173.00 | |
200 mg | In stock | $ 259.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity. |
Targets&IC50 | Mpro:0.67 μM (IC50), COVID-19 virus:4.67 μM (EC50) |
Synonyms | SPI-1005, PZ-51, CCG-39161 |
Molecular Weight | 274.18 |
Formula | C13H9NOSe |
CAS No. | 60940-34-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mM
H2O: Insoluble
You can also refer to dose conversion for different animals. More
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Ebselen 60940-34-3 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience Proteases/Proteasome Virus Protease Phosphatase Calcium Channel HIV Protease COX voltage-dependent IMPase Ca channels VDCC peroxidase COVID-19 SPI-1005 C145 HIV blood-brain PZ-51 QSOX1 inositol monophosphatase Ca2+ channels Human immunodeficiency virus Mpro barrier glutathione SPI1005 SPI 1005 Inhibitor PZ51 CCG-39161 CCG39161 CCG 39161 PZ 51 inhibit mimetic inhibitor