keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxidase in neurons, thereby blocking the production of superoxide, which reduces ischemic injury in the acute phase after stroke.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | In stock | $ 99.00 |
Description | Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxidase in neurons, thereby blocking the production of superoxide, which reduces ischemic injury in the acute phase after stroke. |
Targets&IC50 | PSD-95d1:670 nM (EC50), PSD-95d2:6.7 nM (EC50) |
In vitro | Similar to the NR2 subunits, Tat-NR2B9c binds to PSD-95d1 and PSD-95d2, and this binding is independent of PDZ interactions, with respective ED50 values of 0.67 μM and 0.067 μM[2]. |
In vivo | Tat-NR2B9c (10 nmol/g, IV) reduced infarct volume by 24.5% and 26.0% following 30 and 60 minutes of tMCAO, respectively, but had no effect on mice at a dose of 3 nM/g[3]. |
Synonyms | Tat-NR2Bct, NA-1 |
Molecular Weight | 2518.88 |
Formula | C105H188N42O30 |
CAS No. | 500992-11-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 80 mg/mL (224.57 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Tat-NR2B9c 500992-11-0 Immunology/Inflammation Membrane transporter/Ion channel Neuroscience iGluR NO Synthase Tat NR2B9c Tat-NR2Bct Tat-NR-2B9c NA 1 TatNR2B9c NA-1 NA1 inhibitor inhibit