20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9122 | XL177A | DUB | |
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism. | |||
T9636 | Dalpiciclib | SHR-6390 | CDK |
Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag... | |||
T16745 | Rhosin hydrochloride | Apoptosis , Rho , Ras | |
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o... | |||
T5755 | Aloesin | Tyrosinase | |
Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin. | |||
T9629 | BRD4 Inhibitor-24 | Epigenetic Reader Domain | |
BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity. | |||
T2679 | BMS-265246 | BMS265246 | CDK |
BMS-265246 is a potent and selective CDK1/2 inhibitor. | |||
T9205 | NCGC00378430 | Phosphatase , Others | |
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis. | |||
T60002 | DC-S239 | Histone Methyltransferase | |
DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity. | |||
T9605 | Sangivamycin | BA-90912,NSC 65346 | Nucleoside Antimetabolite/Analog , PKC |
Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers. | |||
T12134 | MYCMI-6 | NSC354961 | Apoptosis , c-Myc |
MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without seve... | |||
T8334 | CADD522 | MFCD00167693 | Others |
CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity | |||
T4459 | PK11000 | DNA Alkylator/Crosslinker | |
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. | |||
T8649 | TMBIM6 antagonist-1 | BAX-inhibitor-1,BIA | mTOR |
TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor | |||
T6018 | Zosuquidar trihydrochloride | Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride | P-gp |
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3. | |||
T9078 | LY3405105 | 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester | CDK |
LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors. | |||
T17155 | Trabectedin | Ecteinascidin 743,ET-743 | Apoptosis , Reactive Oxygen Species |
Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research. Trabectedin inhibits cell growth of MX-1, MCF7 and MCF7/DXR cells with IC50 values of 0... | |||
T7311 | Oxyphenisatin acetate | Autophagy | |
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. | |||
T5132 | 9-dihydro-13-acetylbaccatin III | 13-Acetyl-9-dihydrobaccatin III,9-DHAB III | Apoptosis |
9-dihydro-13-acetylbaccatin III (9-DHAB III)is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR. | |||
TQ0232 | UNC0646 | UNC 0646 | Histone Methyltransferase |
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ... | |||
T69860 | PSB-15160 | ||
PSB-15160 is a compound that inhibits the growth of MCF7 (breast), NCI-H460 (lung) and SF-268 (NCS) cells in the treatment of estrogen-dependent tumours. |