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UNC0646

Catalog No. TQ0232 CAS 1320288-17-2

Synonyms: UNC 0646

UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

UNC0646, CAS 1320288-17-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 58.00
10 mg	In stock	$ 103.00
25 mg	In stock	$ 192.00
50 mg	In stock	$ 342.00
100 mg	In stock	$ 497.00
1 mL * 10 mM (in DMSO)	In stock	$ 88.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
Targets&IC50	G9a:6 nM, GLP:15 nM

Synonyms	UNC 0646
Molecular Weight	621.9
Formula	C36H59N7O2
CAS No.	1320288-17-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (48.24 mM), Sonication is recommended.

References and Literature

1. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Chromatin Modification Compound Library Reprogramming Compound Library Anti-Diabetic Compound Library Methylation Compound Library Bioactive Compounds Library Max Epigenetics Compound Library NO PAINS Compound Library Histone Modification Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC0646 1320288-17-2 Chromatin/Epigenetic Histone Methyltransferase H3K9me2 KMT1D UNC 0646 UNC-0646 chromatin EHMT1 SAR inhibit G9a GLP PKMT Inhibitor cell-penetration p53 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.