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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36526 | IL-17 modulator 4 | Interleukin | |
IL-17 modulator 4 is a prodrug of IL-17 modulator 1 which is an efficacious modulator of IL-17. | |||
T36527 | IL-4-inhibitor-1 | IL Receptor | |
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhib... | |||
T40107 | IL-17 modulator 4 sulfate | ||
IL-17 modulator 4 sulfate is a prodrug of IL-17 modulator 1 . IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. | |||
T9926 | Omalizumab | Others | |
Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E IgE) | |||
T9631 | IRAK-4 protein kinase inhibitor 2 | IRAK | |
IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM). | |||
T11673 | IRAK4-IN-4 | IRAK , cGAS | |
IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM. | |||
T2457 | IRAK-1-4 Inhibitor I | IRAK-1/4 Inhibitor I,IRAK-1/4 Inhibitor | IRAK |
IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1. | |||
TN6722 | Terminolic acid | 2α,6β,23-trihydroxyl oleanolic acid | Antibacterial |
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and ... | |||
T22338 | 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | GDC046 | Others , JAK |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile. | |||
T4140 | IRAK4-IN-1 | IRAK | |
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. | |||
T9043 | AS1810722 | P450 , STAT | |
AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f... | |||
T4299 | AS-2444697 | IRAK | |
AS-2444697 is an inhibitor of IRAK-4 (C50 = 21 nM). AS-2444697 exhibits renoprotective effects through anti-inflammatory action. AS-2444697 potently inhibits human and rat IRAK-4 activity. | |||
T14367 | AZ1495 | IRAK , CDK , Haspin Kinase | |
AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu... | |||
T5354 | IRAK4-IN-7 | CA-4948 | IRAK |
IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model. | |||
T3965 | Fevipiprant | QAW039,NVP-QAW039 | GPR , Prostaglandin Receptor |
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. | |||
T63089 | (R)-IL-17 modulator 4 | ||
(R)-IL-17 modulator 4 is the R-configured form of IL-17 modulator 4 and is a prodrug of IL-17 modulator 1. IL-IL-17 modulator 1 is a potent, orally active IL-17 modulator. | |||
T25465 | GS143 | GS-143,GS 143 | IκB/IKK , E1/E2/E3 Enzyme , NF-κB |
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea... | |||
T0117 | Suplatast (Tosilate) | IPD 1151T,Suplatast tosilate,Suplatast Tosylate | IL Receptor , Interleukin |
Suplatast Tosilate (IPD 1151T) is a novel capsular anti-asthmatic drug. It ( IC50 above 100 μM) inhibits both IgE production, IL-4 and IL-5 synthesis. | |||
TN1416 | Ayanin | IL Receptor , P450 , PARP , PDE | |
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 productio... | |||
T9840 | Ataquimas | Immunology/Inflammation related | |
Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells. |