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Search Result

Search Results for " il-17a "

Targets

IL Receptor

39

Compounds

2

Natural Products

20

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11635 IL-17A antagonist 1 IL Receptor
IL-17A antagonist 1 is an IL-17A antagonist for the study of interleukin-related inflammatory and immune diseases.
T9448 IL-17A inhibitor 1 IL Receptor
IL-17A inhibitor 1 is a IL-17A inhibitor with IC50 of <9.45 nM in alphalisa assay. IL-17A inhibitor 1 inhibits HT-29 cells with IC50 of 9.3 nM.
T40355 IL-17A modulator-2
IL-17A modulator-2, exhibits inhibitory properties towards IL-17A, with a pIC50 of 8.3. Its effectiveness lies in attenuating the biological effects associated with IL-17A activity. IL-17A modulator-2 finds utility in th...
T40354 IL-17A modulator-1
IL-17A modulator-1 is an effective inhibitor of IL-17A activity, exhibiting a pIC 50 value of 8.2. This compound holds great promise for studying diseases and disorders that involve the modulation of IL-17A, such as immu...
T40116 IL-17A inhibitor 2
IL-17A inhibitor 2 is an IL-17A inhibitor for treating psoriasis, rheumatoid arthritis, and multiple sclerosis.
T11636 IL-17A antagonist 3 IL Receptor
IL-17A antagonist 3 is an IL-17A antagonist.
T14369 AZD-0284 ROR
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
T76797 Anti-Human IL-17A
Anti-Human IL-17A is a fully human anti- interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis [1] .
T72549 IL-17A modulator-3
IL-17A Modulator-3, an inhibitor of IL-17A/A, exhibits an IC 50 value of less than 10 μM. It is utilized in research related to inflammation, cancer, and autoimmune diseases.
T6668 SGC-CBP30 Epigenetic Reader Domain , Histone Acetyltransferase
SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
T4050 GSK2981278 ROR gama modulator 1 ROR
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
T38105 Ixekizumab LY2439821 IL Receptor , Interleukin
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A with a Kd value of <3 pM.Ixekizumab blocks the binding of IL-17A to IL-17RA but not to other IL-17 ...
T4403 AX-024 hydrochloride AX-024 HCl IL Receptor , TNF , COX , IFNAR , Interleukin
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
T9930 Secukinumab IL Receptor
Secukinumab is a fully humanized monoclonal anti-IL-17A antibody and the first in its class to be approved by the US Food and Drug Administration for the treatment of moderate to severe plaque psoriasis.
T77677 12R-LOX-IN-2 Lipoxygenase
12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein...
T76256 Erepdekinra
Erepdekinra is an interleukin-17A (IL-17A) receptor antagonist [1] .
T77030 Gumokimab
Gumokimab (AK 111), a monoclonal antibody, targets IL-17A and is utilized in researching psoriasis and ankylosing spondylitis. It competitively inhibits the interaction between human IL-17A and its receptor, IL-17R.
T71573 STK630921
STK630921 is a blocker of IL-17A binding to the IL-17A receptor (IL-17RA).
T76953 Xeligekimab
Xeligekimab (GR 1501) is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A) to inhibit the pro-inflammatory cascade [1].
T76901 Afasevikumab
Afasevikumab (RG 7624; RO 5553110; NI-1401), a fully human monoclonal IgG1κ antibody, neutralizes both IL-17A and IL-17F, exhibiting anti-inflammatory activities [1].
T79024 Androgen receptor-IN-5 Androgen Receptor
Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties. It additionally suppresses the synthesis of IL-17A, IL-17F, and INF-γ.
T63124 RORγt modulator 4
RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen.
T77179 Remtolumab
Remtolumab (ABT-122), a dual-variable domain immunoglobulin, neutralizes tumor necrosis factor α (TNFα) and IL-17A, demonstrating dual inhibition of both. This compound is utilized in rheumatoid arthritis (RA) research [...
T12750 ROR agonist-1 Others
ROR agonist-1 is a potent and orally bioavailable the retinoic acid receptor-related orphan receptor C2 (RORC2) inverse agonist(inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5).
T11308 FM26 ROR
FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC5...
T76798 Bimekizumab
Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody), a humanized monoclonal antibody, selectively neutralizes IL-17A and IL-17F, both of which promote osteogenic differentiation in human periosteum-derived cells (...
T25109 ARN-6039 ARN 6039,ARN6039
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE...
T70065 JNJ-61803534
JNJ-61803534 is a potent, orally active RORγt inverse agonist, demonstrating anti-inflammatory activity through inhibition of IL-17A production in human CD4+ T cells under Th17 differentiation conditions, with an IC50 of...
T76823 Perakizumab
Perakizumab (RG4934), a humanized IgG1κ monoclonal antibody targeting IL-17A (Interleukin Related), is utilized in the study of autoimmune conditions, including psoriatic arthritis [1].
T10210 A-9758 ROR
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 s...
T76981 Tibulizumab
Tibulizumab (LY 3090106), a tetravalent bispecific monoclonal antibody, selectively binds to B-cell activating factor (BAFF) and IL-17A with dissociation constants (Kd) of 60 pM and 14 pM, respectively. This specificity ...
T40043 RORγt Inverse agonist 10
RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel...
T62622 MRL-871
MRL-871 (compound 3) is a potent isotretinoin receptor-related orphan receptor γt (RORγt) inverse agonist (IC50: 264 nM).MRL-871 has a specific isoxazole chemotype and is effective in reducing IL-17a mRNA production in E...
T83457 12R-LOX-IN-1
12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX. It suppresses the hyperproliferative condition and the ability to form colonies in Imiquimod-induced psoriatic keratinocytes, as well as r...
T76885 Sonelokimab
Sonelokimab (ALX 0761; M 1095) is a trivalent nanobody that combines monovalent camelid-derived nanobodies targeting human interleukin (IL)-17A and IL-17F, along with human serum albumin VHHs. This composition presents s...
T36998 7β,27-dihydroxy Cholesterol 7β,27-DHC,7β,27-dihydroxy Cholesterol
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, res...
T61071 AX-024
AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. Wi...
T64300 Vimirogant hydrochloride
Vimirogant (VTP-43742) hydrochloride is an orally active, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM) that is more than 1000 times more selective than RORα and RORβ. Vimirogant hydrochloride inhibits Th17 differe...
T76840 Vunakizumab
Vunakizumab (Anti-Human IL17A Recombinant Antibody), a recombinant human IgGκ monoclonal antibody, specifically targets and inhibits IL-17A's interaction with its receptor, making it useful for researching autoimmune con...

Compounds

IL-17A antagonist 1
T11635
Synonym:
Target: IL Receptor
IL-17A inhibitor 1
T9448
Synonym:
Target: IL Receptor
IL-17A modulator-2
T40355
Synonym:
Target:
IL-17A modulator-1
T40354
Synonym:
Target:
IL-17A inhibitor 2
T40116
Synonym:
Target:
IL-17A antagonist 3
T11636
Synonym:
Target: IL Receptor
AZD-0284
T14369
Synonym:
Target: ROR
Anti-Human IL-17A
T76797
Synonym:
Target:
IL-17A modulator-3
T72549
Synonym:
Target:
SGC-CBP30
T6668
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
GSK2981278
T4050
Synonym: ROR gama modulator 1
Target: ROR
Ixekizumab
T38105
Synonym: LY2439821
Target: IL Receptor, Interleukin
AX-024 hydrochloride
T4403
Synonym: AX-024 HCl
Target: IL Receptor, TNF, COX, IFNAR, Interleukin
Secukinumab
T9930
Synonym:
Target: IL Receptor
12R-LOX-IN-2
T77677
Synonym:
Target: Lipoxygenase
Erepdekinra
T76256
Synonym:
Target:
Gumokimab
T77030
Synonym:
Target:
STK630921
T71573
Synonym:
Target:
Xeligekimab
T76953
Synonym:
Target:
Afasevikumab
T76901
Synonym:
Target:
Androgen receptor-IN-5
T79024
Synonym:
Target: Androgen Receptor
RORγt modulator 4
T63124
Synonym:
Target:
Remtolumab
T77179
Synonym:
Target:
ROR agonist-1
T12750
Synonym:
Target: Others
FM26
T11308
Synonym:
Target: ROR
Bimekizumab
T76798
Synonym:
Target:
ARN-6039
T25109
Synonym: ARN 6039,ARN6039
Target:
JNJ-61803534
T70065
Synonym:
Target:
Perakizumab
T76823
Synonym:
Target:
A-9758
T10210
Synonym:
Target: ROR
Tibulizumab
T76981
Synonym:
Target:
RORγt Inverse agonist 10
T40043
Synonym:
Target:
MRL-871
T62622
Synonym:
Target:
12R-LOX-IN-1
T83457
Synonym:
Target:
Sonelokimab
T76885
Synonym:
Target:
7β,27-dihydroxy Cholesterol
T36998
Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol
Target:
AX-024
T61071
Synonym:
Target:
Vimirogant hydrochloride
T64300
Synonym:
Target:
Vunakizumab
T76840
Synonym:
Target:
Cat No. Product Name Synonyms Targets
TN7236 Cephalandole B IL Receptor
cephalandole B, an indole alkaloid isolated from cyanide, significantly inhibited IL-17A gene expression and suppressed IL-17A luciferase reporter in Jukat cells in a dose-dependent manner.
TN6393 Fulvotomentoside A Others
Fulvotomentoside A could decrease overexpression of IL-6 and IL-17A, and increase the expression of specific transcription factor Foxp3 of regulatory T cells significantly in intestine. It may be one of the mechanisms th...

Natural Products

Cephalandole B
TN7236
Synonym:
Target: IL Receptor
fulvotomentoside A
TN6393
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (9)
Mouse (5)
Cynomolgus (4)
Rat (1)
Rhesus (1)
Expression System：
HEK293 Cells (10)
E. coli (7)
Baculovirus Insect Cells (2)
P. pastoris (Yeast) (1)
Tag：
Tag Free (6)
C-His-Avi (5)
C-His (3)
N-His (3)
C-6xHis (2)
N-6xHis (1)
Cat No. Product Name Species Expression System
TMPY-00470 IL-17A & IL-17F Heterodimer Protein, Human, Recombinant (His) Human HEK293 Cells
IL-17A & IL-17F Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is NP_002181.1&NP_443104.1.
TMPY-00053 IL-17A & IL-17F Heterodimer Protein, Human, Recombinant Human E. coli
IL-17A & IL-17F Heterodimer Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30.7 kDa and the accession number is Q16552&NP_443104.1.
TMPY-02900 IL-17A Protein, Mouse, Recombinant Mouse E. coli
IL-17A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.5 kDa and the accession number is Q62386.
TMPY-02886 IL-17A Protein, Human, Recombinant Human E. coli
IL-17A Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.7 kDa and the accession number is Q16552.
TMPY-03568 IL-17A Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
IL-17A Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q16552.
TMPJ-01444 IL-17A Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it ...
TMPY-05183 IL-17A Protein, Human, Recombinant, Biotinylated Human E. coli
IL-17A Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 15.7 kDa and the accession number is Q16552.
TMPY-04332 IL-17A Protein, Human, Recombinant (T26A, His) Human Baculovirus Insect Cells
IL-17A Protein, Human, Recombinant (T26A, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q16552.
TMPJ-01172 IL-17 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque...
TMPK-01036 IL-17A Protein, Mouse, Recombinant (His & Avi) Mouse HEK293 Cells
IL-17A Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18 kDa and the accession number is Q62386-1.
TMPK-00975 IL-17A Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
IL-17A Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.2 kDa and the accession number is Q16552-1.
TMPK-01037 IL-17A Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse HEK293 Cells
IL-17A Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18 kDa and the accession number is Q62386-1.
TMPK-01266 IL-17A Protein, Cynomolgus, Recombinant (His & Avi) Cynomolgus HEK293 Cells
IL-17A Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.2 kDa and the accession number is A0A2K5TTB0.
TMPY-05342 IL-17A Protein, Cynomolgus, Recombinant Cynomolgus Baculovirus Insect Cells
IL-17A Protein, Cynomolgus, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.1 kDa and the accession number is A0A2K5TTB0.
TMPH-03319 IL-17A Protein, Rat, Recombinant (His) Rat E. coli
IL-17A Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.0 kDa and the accession number is Q61453.
TMPY-04728 IL-17A & IL-17F Heterodimer Protein, Rhesus, Recombinant (His) Rhesus HEK293 Cells
IL-17A & IL-17F Heterodimer Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.5 kDa and the accession number is XP_001106391.1&NP_001248216.1.
TMPK-00060 IL-17B Protein, Mouse, Recombinant (His) Mouse E. coli
IL-17A, the prototypic member of the IL-17 family, several experimental findings strongly support the role of the IL-17B/IL-17 receptor B (IL-17RB) pathway in tumorigenesis and resistance to anticancer therapies. IL-17B/...
TMPK-00668 IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His) Cynomolgus HEK293 Cells
IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by...
TMPJ-00046 IL-17F Protein, Human, Recombinant Human E. coli
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally relate...
TMPK-00084 IL-17C Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Interleukin‑17C (IL‑17C) is a 15‑20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conser...
IL-17A & IL-17F Heterodimer Protein, Human, Recombinant (His)
TMPY-00470
Species: Human
Expression System: HEK293 Cells
IL-17A & IL-17F Heterodimer Protein, Human, Recombinant
TMPY-00053
Species: Human
Expression System: E. coli
IL-17A Protein, Mouse, Recombinant
TMPY-02900
Species: Mouse
Expression System: E. coli
IL-17A Protein, Human, Recombinant
TMPY-02886
Species: Human
Expression System: E. coli
IL-17A Protein, Human, Recombinant (His)
TMPY-03568
Species: Human
Expression System: P. pastoris (Yeast)
IL-17A Protein, Cynomolgus, Recombinant (His)
TMPJ-01444
Species: Cynomolgus
Expression System: HEK293 Cells
IL-17A Protein, Human, Recombinant, Biotinylated
TMPY-05183
Species: Human
Expression System: E. coli
IL-17A Protein, Human, Recombinant (T26A, His)
TMPY-04332
Species: Human
Expression System: Baculovirus Insect Cells
IL-17 Protein, Mouse, Recombinant (His)
TMPJ-01172
Species: Mouse
Expression System: HEK293 Cells
IL-17A Protein, Mouse, Recombinant (His & Avi)
TMPK-01036
Species: Mouse
Expression System: HEK293 Cells
IL-17A Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00975
Species: Human
Expression System: HEK293 Cells
IL-17A Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPK-01037
Species: Mouse
Expression System: HEK293 Cells
IL-17A Protein, Cynomolgus, Recombinant (His & Avi)
TMPK-01266
Species: Cynomolgus
Expression System: HEK293 Cells
IL-17A Protein, Cynomolgus, Recombinant
TMPY-05342
Species: Cynomolgus
Expression System: Baculovirus Insect Cells
IL-17A Protein, Rat, Recombinant (His)
TMPH-03319
Species: Rat
Expression System: E. coli
IL-17A & IL-17F Heterodimer Protein, Rhesus, Recombinant (His)
TMPY-04728
Species: Rhesus
Expression System: HEK293 Cells
IL-17B Protein, Mouse, Recombinant (His)
TMPK-00060
Species: Mouse
Expression System: E. coli
IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His)
TMPK-00668
Species: Cynomolgus
Expression System: HEK293 Cells
IL-17F Protein, Human, Recombinant
TMPJ-00046
Species: Human
Expression System: E. coli
IL-17C Protein, Human, Recombinant (His & Avi)
TMPK-00084
Species: Human
Expression System: HEK293 Cells
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