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AZD-0284

Name: AZD-0284
Brand: TargetMol
SKU: T14369
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14369Cas No. 2101291-07-8

AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].

AZD-0284

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Purity: 99.82%

Catalog No. T14369Cas No. 2101291-07-8

AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	In Stock	In Stock
5 mg	$96	In Stock	In Stock
10 mg	$146	In Stock	In Stock
25 mg	$226	In Stock	In Stock
50 mg	$327	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$112	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.82%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
Targets&IC50	RORγ:7.4(pIC50)
In vitro	AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells[1], reduces polarization of TH17 into pathogenic TH17/1 cells, decreases the frequency of IL-17+ cells and double positive TH17/1 cells, and reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22, and IL-23R[1][2].

Chemical Properties

Molecular Weight	524.43
Formula	C₂₁H₁₈F₆N₂O₅S
Cas No.	2101291-07-8
Smiles	CC(=O)N1Cc2cc(ccc2[C@@H]1C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(C)(=O)=O
Relative Density.	1.534 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 99 mg/mL (188.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (1.91 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9068 mL	9.5342 mL	19.0683 mL	95.3416 mL
5 mM	0.3814 mL	1.9068 mL	3.8137 mL	19.0683 mL
10 mM	0.1907 mL	0.9534 mL	1.9068 mL	9.5342 mL
20 mM	0.0953 mL	0.4767 mL	0.9534 mL	4.7671 mL
50 mM	0.0381 mL	0.1907 mL	0.3814 mL	1.9068 mL
100 mM	0.0191 mL	0.0953 mL	0.1907 mL	0.9534 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc