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GSK2981278

Catalog No. T4050   CAS 1474110-21-8
Synonyms: ROR gama modulator 1

GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).

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GSK2981278 Chemical Structure
GSK2981278, CAS 1474110-21-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
2 mg In stock $ 48.00
5 mg In stock $ 78.00
10 mg In stock $ 118.00
25 mg In stock $ 198.00
50 mg In stock $ 336.00
100 mg In stock $ 498.00
500 mg In stock $ 1,130.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.78%
Purity: 99.59%
Purity: 99.52%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
Synonyms ROR gama modulator 1
Molecular Weight 461.61
Formula C25H35NO5S
CAS No. 1474110-21-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (108.31 mM)

TargetMolReferences and Literature

1. Birault Veronique, et al. Preparation of tetrahydropyranylmethoxy benzenesulfonamide compounds as RORγ modulators useful in therapy of various diseases. From PCT Int. Appl. (2015), WO 2015061515 A1 20150430. 2. Birault Veronique, et al. Preparation of tertiary N-arylbenzenesulfonamides as RORγ modulators useful in treatment of inflammatory, metabolic, and autoimmune diseases. From PCT Int. Appl. (2013), WO 2013160418 A1 20131031.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Kinase Inhibitor Library Immunology/Inflammation Compound Library Inhibitor Library ReFRAME Related Library Nuclear Receptor Compound Library Covalent Inhibitor Library Anti-COVID-19 Compound Library Lipid Metabolism Compound Library Bioactive Compounds Library Max

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Keywords

GSK2981278 1474110-21-8 Metabolism ROR IL-22,ointment RAR-related orphan receptor psoriasis topically inflammation il17 inverse GSK 2981278 GSK-2981278 binding,IL-17A ROR gama modulator 1 inhibit RORγ-DNA Inhibitor inhibitor

 

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