icam-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13147	ICAM-1-IN-1		Integrin
	ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.		Integrin
T21781	A-286982		Integrin
	A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.		Integrin
T3638	Leukadherin-1		Integrin , Complement System
	Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.		Integrin , Complement System
T2254	A-205804		Integrin
	A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.		Integrin
T8132	Iron sucrose	Iron saccharate,Sucroferric oxyhydroxide	Reactive Oxygen Species
	Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.		Reactive Oxygen Species
T3977	Lifitegrast	SHP-606,SAR 1118	Integrin
	Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.		Integrin
T12783	RWJ 50271		Integrin
	RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells).		Integrin
T14676	BMS-688521		Integrin
	BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.		Integrin
T76927	Bersanlimab	BI-505	Integrin
	Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties and can be used to study relapsed/refractory multiple myeloma.		Integrin
T23796	BIRT-377	BIRT377,BIRT 377	IL Receptor , Integrin
	BIRT-377 is a negative allosteric and orally bioavailable inhibitor of ICAM-1 and LFA-1(Ki = 25.8 nM). BIRT-377 inhibits the production of IL-2 and can be used in studies about inflammatory and immune disorders.		IL Receptor , Integrin
T5785	MALTOTETRAOSE	Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose	TNF , Endogenous Metabolite
	Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development.		TNF , Endogenous Metabolite
TN1163	2'-Hydroxychalcone		Others
	2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxyc...		Others
TN6694	5,6-Benzoflavone	β-Naphthoflavone,beta-NF	Antioxidant
	5,6-Benzoflavone (β-Naphthoflavone) is an exogenous ligand for the aryl hydrocarbon receptor, which disrupts zinc homeostasis in human hepatocellular carcinoma HepG2 cells. 5,6-Benzoflavone (β-Naphthoflavone) possesses a...		Antioxidant
T0468	Lidocaine	Lignocaine,Alphacaine,Xylocaine	Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor
	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat...
T2873	Ginsenoside Rg2	Chikusetsusaponin I,Panaxoside Rg2,Prosapogenin C2,(20S)Ginsenoside Rg2	Beta Amyloid , GSK-3 , NF-κB
	Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.		Beta Amyloid , GSK-3 , NF-κB
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T24155	ICAM-1988	ICAM 1988
	ICAM-1988 is a LFA-1 antagonist.
T64233	Alicaforsen
	Alicaforsen is a 20 base length antisense oligonucleotide that exhibits an inhibitory effect on ICAM-1 production. ICAM-1 is an important adhesion molecule that is involved in the migration and transport of leukocytes to...
T38976	MUC1, mucin core	MUC1, mucin core
	MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1.
T74435	Alicaforsen sodium
	Alicaforsen sodium is a 20-base antisense oligonucleotide that targets and inhibits the production of ICAM-1, a critical adhesion molecule responsible for mediating leukocyte migration and trafficking toward inflammation...