Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Iron sucrose is treatment of iron deficiency anemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 41.00 | |
200 mg | In stock | $ 58.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Iron sucrose is treatment of iron deficiency anemia. |
In vitro | In vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P <?0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P <?0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P <?0.001).?Cytotoxicity of iron towards mesothelial cells was enhanced in vitro when it was tested in presence of the dialysis fluid.?Iron used in vitro at concentration 0.0001 mg mL-1 and greater induces generation of oxygen-derived free radicals in mesothelial cells.?Furthermore, iron is taken by these cells and stored in their cytosol, resulting in stimulation of the intracellular generation of free radicals[1]. |
Cell Research | in vitro experiments on human peritoneal, the mesothelial effect of elemental iron (in conc. 0.0001-1 mg mL-1) present in Venofer on their viability, growth and synthesis of IL-6 was studied. Additionally we evaluated with a fluorescent probe (2',7'-dichlorodihydro-fluorescein diacatate) generation of reactive oxygen species in cells exposed to iron sucrose. We also measured accumulation of iron in the cytoplasm of mesothelial cells after their in vitro exposure to Venofer[1]. |
Synonyms | Iron saccharate, Sucroferric oxyhydroxide |
Molecular Weight | 736.1 |
Formula | C18H24Fe2O24 |
CAS No. | 8047-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 100 mg/mL (135.85 mM)
H2O: 100 mg/mL (135.85 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Iron sucrose 8047-67-4 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species H2O2 pregnancy ascorbate IDA Intravenous ICAM-1 inhibit NADPH Iron saccharate NF-κB Sucroferric oxyhydroxide Inhibitor VCAM-1 hemoglobin anemia iron safe inhibitor