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Iron sucrose

Catalog No. T8132 CAS 8047-67-4

Synonyms: Iron saccharate, Sucroferric oxyhydroxide

Iron sucrose is treatment of iron deficiency anemia.

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Iron sucrose, CAS 8047-67-4

Pack Size	Availability	Price/USD
100 mg	In stock	$ 41.00
200 mg	In stock	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Storage & Solubility Information

Description	Iron sucrose is treatment of iron deficiency anemia.
In vitro	In vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P <?0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P <?0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P <?0.001).?Cytotoxicity of iron towards mesothelial cells was enhanced in vitro when it was tested in presence of the dialysis fluid.?Iron used in vitro at concentration 0.0001 mg mL-1 and greater induces generation of oxygen-derived free radicals in mesothelial cells.?Furthermore, iron is taken by these cells and stored in their cytosol, resulting in stimulation of the intracellular generation of free radicals[1].
Cell Research	in vitro experiments on human peritoneal, the mesothelial effect of elemental iron (in conc. 0.0001-1 mg mL-1) present in Venofer on their viability, growth and synthesis of IL-6 was studied. Additionally we evaluated with a fluorescent probe (2',7'-dichlorodihydro-fluorescein diacatate) generation of reactive oxygen species in cells exposed to iron sucrose. We also measured accumulation of iron in the cytoplasm of mesothelial cells after their in vitro exposure to Venofer[1].

Synonyms	Iron saccharate, Sucroferric oxyhydroxide
Molecular Weight	736.1
Formula	C18H24Fe2O24
CAS No.	8047-67-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (135.85 mM)

H2O: 100 mg/mL (135.85 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Breborowicz M , Polubinska A , Tam P , et al. Effect of iron sucrose on human peritoneal mesothelial cells[J]. European Journal of Clinical Investigation, 2003, 33(12):1038-1044. 2. Kaneva K , Chow E , Rosenfield C G , et al. Intravenous Iron Sucrose for Children With Iron Deficiency Anemia[J]. Journal of Pediatric Hematology/oncology, 2017:1.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Prostate Cancer Compound Library Anti-Breast Cancer Compound Library Approved Drug Library Pyroptosis Compound Library Immunology/Inflammation Compound Library Anti-Cancer Approved Drug Library Anti-Liver Cancer Compound Library Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library NF-κB Signaling Compound Library

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Keywords

Iron sucrose 8047-67-4 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species H2O2 pregnancy ascorbate IDA Intravenous ICAM-1 inhibit NADPH Iron saccharate NF-κB Sucroferric oxyhydroxide Inhibitor VCAM-1 hemoglobin anemia iron safe inhibitor

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