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2'-Hydroxychalcone

Catalog No. TN1163   CAS 1214-47-7

2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2'-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-α, tumor necrosis factor-α, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.

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2'-Hydroxychalcone Chemical Structure
2'-Hydroxychalcone, CAS 1214-47-7
Pack Size Availability Price/USD Quantity
100 mg In stock $ 50.00
500 mg In stock $ 65.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2'-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-α, tumor necrosis factor-α, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.
Targets&IC50 mTOR:12 µM
Molecular Weight 224.25
Formula C15H12O2
CAS No. 1214-47-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (122.63 mM)

TargetMolReferences and Literature

1. Roy T, et al. Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers. Bioorg Chem. 2021;107:104595.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Tumor Natural Product Library Selected Plant-Sourced Compound Library Flavonoid Natural Product Library Natural Product Library for HTS Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

2'-Hydroxychalcone 1214-47-7 Others 1(2Hydroxyphenyl)3phenyl2propenone 1 (2 Hydroxyphenyl) 3 phenyl 2 propenone inhibitor inhibit

 

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