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BMS-688521

Catalog No. T14676 CAS 893397-44-9

BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.

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BMS-688521, CAS 893397-44-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 259.00
5 mg	In stock	$ 635.00
10 mg	In stock	$ 859.00
25 mg	In stock	$ 1,520.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
1 mL * 10 mM (in DMSO)	In stock	$ 749.00

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Biological Description

Chemical Properties

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Description	BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.
Targets&IC50	ICAM1:78 nM
In vitro	BMS-688521 inhibits the specific adhesion of mouse splenocytes and a mouse ICAM-1 expressing cell line, b.END3, with an IC50 of 78 nM[1].
In vivo	In BALB/c female mice, 6-8 weeks of age (OVA Lung Inflammation in Mice), BMS-688521 (1, 3, and 10 mg/kg; p.o.; BID for three days) exhibited significant inhibition of eosinophil accumulation at a dose of 1 mg/kg BID, with dose-dependent inhibition observed at 3 mg/kg and 10 mg/kg[1].

Molecular Weight	536.37
Formula	C26H19Cl2N5O4
CAS No.	893397-44-9

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (149.15 mM), Sonication is recommended.

References and Literature

1. Watterson SH, et al. Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). J Med Chem. 2010 May 13;53(9):3814-30.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-688521 893397-44-9 Cytoskeletal Signaling Integrin BMS 688521 BMS688521 inhibitor inhibit

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