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ICAM-1-IN-1

Catalog No. T13147 CAS 251994-14-6

ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.

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ICAM-1-IN-1, CAS 251994-14-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.
Targets&IC50	ICAM-1:5 nM , E-selectin:7 nM
In vivo	In a rat rheumatoid arthritis model and in a mouse asthma model,ICAM-1-IN-1 shows significant efficacy . the width of inflamed ankles after the ninth day following treatment reduced by ICAM-1-IN-1, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.

Molecular Weight	363.23
Formula	C15H11BrN2O2S
CAS No.	251994-14-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 135 mg/mL (371.67 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ICAM-1-IN-1 251994-14-6 Cytoskeletal Signaling Integrin ICAM 1 IN 1 inhibit ICAM1IN1 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.