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Search Result

Search Results for " ht7 "

Targets

5-HT Receptor

53

Compounds

1

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10170 5-HT7 agonist 1 4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole 5-HT Receptor
5-HT7 agonist 1 (4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole) is a selective agonist of 5-HT7 (IC50 = 222.93 nM). 5-HT7 agonist 1 can be used in studies about CNS disorders.
T61375 5-HT7 agonist 2
5-HT7 agonist 2 is a highly potent 5-HT7 receptor agonist, exhibiting an IC50 value of 28.7 nM. This compound holds promise for studying and understanding various Central Nervous System (CNS) disorders [1].
T61515 5-HT7 receptor ligand 1
5-HT7 receptor ligand 1 (Compound 5c) is a potent ligand for the 5-HT7 receptor, with a K i value of 8 nM. The compound demonstrates non-hepatotoxic properties and displays moderate potential for drug-drug interactions w...
T60790 5-HT7R antagonist 1
5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.
T39870 5-HT7R antagonist 1 free base 5-HT7R antagonist 1 free base
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.
T12855 SB 258719 5-HT Receptor
SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5).
T6655 SB-269970 hydrochloride SB-269970A,SB269970 HCl 5-HT Receptor
SB-269970 hydrochloride (SB-269970A) , a hydrochloride salt form of SB-269970, is a 5-HT7 receptor antagonist (pKi of 8.3) and exhibits >50-fold selectivity against other receptors.
T11720 JNJ-18038683 5-HT Receptor
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.
T26375 (S)-Amisulpride Esamisulpride,(S) Amisulpride,SEP-4199 Dopamine Receptor , 5-HT Receptor
(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepr...
T5387 LP-211 Dopamine Receptor , 5-HT Receptor
LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor.
T21337 Lurasidone SM-13496 Dopamine Receptor , 5-HT Receptor
Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM).
T23396 ST1936 ST 1936 oxalate 5-HT Receptor
ST1936 (ST 1936 oxalate) is a selective and highly potent 5-HT6 receptor agonist that inhibits human 5-HT6, 5-HT7 and 5-HT2B receptors by fully activating cloned human 5-HT6 receptors. body to stimulate cAMP, Ca2+, ERK1/...
T14782 Brilaroxazine RP5063 Dopamine Receptor , 5-HT Receptor
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...
T26690 AVN-101 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
AVN-101 is a potent 5-HT7 receptor antagonist.
T11326 Frovatriptan succinate hydrate Frovelan,Frova 5-HT Receptor
Frovatriptan succinate hydrate (Frova) is effective in treating the full spectrum of migraine including the associated symptoms of nausea, vomiting, photophobia, and phonophobia. Frovatriptan succinate hydrate can also b...
T1735 Lurasidone hydrochloride Lurasidone HCl,SM-13496 (Hydrochloride),SM-13496 Dopamine Receptor , 5-HT Receptor , Norepinephrine
Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antag...
T24885 Tiospirone BMY 13859-1 Dopamine Receptor , 5-HT Receptor
Tiospirone (BMY 13859-1 free base) is a 5-HT2 receptor antagonist and dopamine blocker that inhibits D2, 5-HT1a, 5-HT7, and sigma receptors.Tiospirone is used in the study of neurological disorders such as schizophrenia.
T4305 8-OH-Dpat 8-Hydroxy-DPAT 5-HT Receptor
8-OH-Dpat (8-Hydroxy-DPAT) is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
T2395L Vortioxetine hydrobromide Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,Lu AA21004 hydrobromide 5-HT Receptor , Serotonin Transporter
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM).
T2395 Vortioxetine Lu AA 21004 5-HT Receptor , Serotonin Transporter
Vortioxetine (Lu AA 21004) is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment.
T4118 SB 271046 hydrochloride SB 271046A 5-HT Receptor
SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and ...
T4008 Metergoline Methergoline,Liserdol Dopamine Receptor , 5-HT Receptor , Sodium Channel
Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
T12842 SB-269970 5-HT Receptor
SB-269970 is a antagonist of 5-HT7 receptor(pKi of 8.3).
T4375 Methiothepin maleate Metitepine 5-HT Receptor
Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
T10380 AS19 5-HT Receptor
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively).
T22750 DR4485 hydrochloride DR 4485 hydrochloride Others
5-HT7 antagonist
T22931 LP 44 Others
5-HT7 receptor agonist
T37816 SB 243213
SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range o...
T22940 LY 215840 Others
5-HT2/5-HT7 receptor antagonist
T37073 LP 12 hydrochloride
LP 12 hydrochloride is a selective 5-HT7 receptor agonist (Ki=0.13 nM). LP 12 hydrochloride is selective for 5-HT7 over D2, 5-HT1A, and 5-HT2A receptors (Ki values of 224 nM, 60.9 nM, and >1000 nM, respectively).
T23319 SB 258719 hydrochloride Others
Selective 5-HT7 receptor antagonist
T22930 LP 20 hydrochloride Others
ligand of the 5-HT7 receptor
T27207 DR-4004 DR4004,DR 4004
DR-4004 is a selective serotonin 5-HT7 receptor antagonist.
T0811L Amisulpride hydrochloride APD-421,Amisulpride HCl,APD 421,APD421,Sultopride
Amisulpride is an antagonist of 5-HT7 receptor and dopamine D2 and D3 receptors. It modulates beta 2- arresting signaling and increases neurite outgrowth.
T13007 ST1936 oxalate 5-HT Receptor
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively).
T62064 PDE4B/7A-IN-2
This compound is a dual 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with additional inhibitory activity against PDE4B/PDE7A (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 ...
T64269 LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate is a selective and potent agonist at the 5-HT7 receptor (Ki: 0.13 nM). LP 12 hydrochloride hydrate is more selective for the 5-HT7 than the D2 receptor (Ki: 224 nM), 5-HT1A receptor (Ki: 60.9 ...
T37212 5-hydroxy-Nω-methyl Tryptamine (oxalate)
5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants. It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay). 5-hydroxy-Nω-me...
T71593 AVN-101 free base
AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a multi-target drug candidate for the treatment of CNS disorders.
T11892 Lurasidone D8 Hydrochloride SM-13496 D8 Others
Lurasidone D8 Hydrochloride is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C, and is the deuterium labeled Lurasidone.
T13308 Vortioxetine D8 Lu AA 21004 D8 Others
Vortioxetine D8 is a deuterium labeled Vortioxetine. Vortioxetine is an 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT inhibitor (Kis: 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively).
T60620 UCSF686
UCSF686 is a UCSF678 analog that is devoid of the 5-HT5A potency, while preserving the off-target affinity (5-HT1A, 5-HT2B and 5-HT7). UCSF686 is recommended as a control compound when using UCSF678 for probing 5-HT5A-de...
T1951 Asenapine Maleate Org 5222 maleate,Org 5222 5-HT Receptor
Asenapine Maleate (Org 5222 maleate) is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar 1 disor...
T6423 BRL-15572 dihydrochloride BRL 15573 dihydrochloride 5-HT Receptor
BRL-15572 dihydrochloride (BRL 15573 dihydrochloride) is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B recepto...
T0074 Chlorprothixene Truxal,Clorprotixeno,Taractan Dopamine Receptor , 5-HT Receptor , Antibacterial , Histamine Receptor
Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized.
T11894 Lusaperidone R107474 Adrenergic Receptor
Lusaperidone (R107474) is a potent α2-adrenergic receptor antagonist, a potential radioligand for the α (2)-adrenergic receptor, with inhibitory effects on α2A and α2C, with Ki values of 0.13 and 0.15 nM, respectively.
T6647 Rotigotine- Neupro,N-0923,N-0437,SPM 962 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Rotigotine (N-0923) is a non-ergot dopamine receptor agonist used in the therapy of Parkinson disease and restless leg syndrome. Administered as a once-daily transdermal patch, Rotigotine has not been associated with ser...
T12899L SEP-363856 hydrochloride SEP-856 hydrochloride Others , 5-HT Receptor
SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to trea...
T21446 Rotigotine Hydrochloride Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,N-0923 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinp...
T22589 Asenapine hydrochloride Others
Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder.

Compounds

5-HT7 agonist 1
T10170
Synonym: 4-[4-[(2-chlorophenyl)methyl]-1-piperazinyl]-1H-indole,4-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-1H-indole,4-[4-(2-chlorobenzyl)piperazino]-1H-indole
Target: 5-HT Receptor
5-HT7 agonist 2
T61375
Synonym:
Target:
5-HT7 receptor ligand 1
T61515
Synonym:
Target:
5-HT7R antagonist 1
T60790
Synonym:
Target:
5-HT7R antagonist 1 free base
T39870
Synonym: 5-HT7R antagonist 1 free base
Target:
SB 258719
T12855
Synonym:
Target: 5-HT Receptor
SB-269970 hydrochloride
T6655
Synonym: SB-269970A,SB269970 HCl
Target: 5-HT Receptor
JNJ-18038683
T11720
Synonym:
Target: 5-HT Receptor
(S)-Amisulpride
T26375
Synonym: Esamisulpride,(S) Amisulpride,SEP-4199
Target: Dopamine Receptor, 5-HT Receptor
LP-211
T5387
Synonym:
Target: Dopamine Receptor, 5-HT Receptor
Lurasidone
T21337
Synonym: SM-13496
Target: Dopamine Receptor, 5-HT Receptor
ST1936
T23396
Synonym: ST 1936 oxalate
Target: 5-HT Receptor
Brilaroxazine
T14782
Synonym: RP5063
Target: Dopamine Receptor, 5-HT Receptor
AVN-101
T26690
Synonym:
Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor
Frovatriptan succinate hydrate
T11326
Synonym: Frovelan,Frova
Target: 5-HT Receptor
Lurasidone hydrochloride
T1735
Synonym: Lurasidone HCl,SM-13496 (Hydrochloride),SM-13496
Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine
Tiospirone
T24885
Synonym: BMY 13859-1
Target: Dopamine Receptor, 5-HT Receptor
8-OH-Dpat
T4305
Synonym: 8-Hydroxy-DPAT
Target: 5-HT Receptor
Vortioxetine hydrobromide
T2395L
Synonym: Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,Lu AA21004 hydrobromide
Target: 5-HT Receptor, Serotonin Transporter
Vortioxetine
T2395
Synonym: Lu AA 21004
Target: 5-HT Receptor, Serotonin Transporter
SB 271046 hydrochloride
T4118
Synonym: SB 271046A
Target: 5-HT Receptor
Metergoline
T4008
Synonym: Methergoline,Liserdol
Target: Dopamine Receptor, 5-HT Receptor, Sodium Channel
SB-269970
T12842
Synonym:
Target: 5-HT Receptor
Methiothepin maleate
T4375
Synonym: Metitepine
Target: 5-HT Receptor
AS19
T10380
Synonym:
Target: 5-HT Receptor
DR4485 hydrochloride
T22750
Synonym: DR 4485 hydrochloride
Target: Others
LP 44
T22931
Synonym:
Target: Others
SB 243213
T37816
Synonym:
Target:
LY 215840
T22940
Synonym:
Target: Others
LP 12 hydrochloride
T37073
Synonym:
Target:
SB 258719 hydrochloride
T23319
Synonym:
Target: Others
LP 20 hydrochloride
T22930
Synonym:
Target: Others
DR-4004
T27207
Synonym: DR4004,DR 4004
Target:
Amisulpride hydrochloride
T0811L
Synonym: APD-421,Amisulpride HCl,APD 421,APD421,Sultopride
Target:
ST1936 oxalate
T13007
Synonym:
Target: 5-HT Receptor
PDE4B/7A-IN-2
T62064
Synonym:
Target:
LP 12 hydrochloride hydrate
T64269
Synonym:
Target:
5-hydroxy-Nω-methyl Tryptamine (oxalate)
T37212
Synonym:
Target:
AVN-101 free base
T71593
Synonym:
Target:
Lurasidone D8 Hydrochloride
T11892
Synonym: SM-13496 D8
Target: Others
Vortioxetine D8
T13308
Synonym: Lu AA 21004 D8
Target: Others
UCSF686
T60620
Synonym:
Target:
Asenapine Maleate
T1951
Synonym: Org 5222 maleate,Org 5222
Target: 5-HT Receptor
BRL-15572 dihydrochloride
T6423
Synonym: BRL 15573 dihydrochloride
Target: 5-HT Receptor
Chlorprothixene
T0074
Synonym: Truxal,Clorprotixeno,Taractan
Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Histamine Receptor
Lusaperidone
T11894
Synonym: R107474
Target: Adrenergic Receptor
Rotigotine-
T6647
Synonym: Neupro,N-0923,N-0437,SPM 962
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
SEP-363856 hydrochloride
T12899L
Synonym: SEP-856 hydrochloride
Target: Others, 5-HT Receptor
Rotigotine Hydrochloride
T21446
Synonym: Rotigotine (Hydrochloride),N 0923,N-0924,Rotigotine HCl,N-0923
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Asenapine hydrochloride
T22589
Synonym:
Target: Others
1 2
Cat No. Product Name Synonyms Targets
T3369 Nuciferine (-)-Nuciferine,VLT 049,Sanjoinine E Dopamine Receptor , 5-HT Receptor
Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.

Natural Products

Nuciferine
T3369
Synonym: (-)-Nuciferine,VLT 049,Sanjoinine E
Target: Dopamine Receptor, 5-HT Receptor

Recombinant Proteins

Species：
Mouse (2)
Human (1)
Expression System：
HEK293 (2)
Human Cells (1)
Tag：
C-Avi-6His (1)
His (1)
His,hFc (1)
Cat No. Product Name Species Expression System
TMPJ-00159 EMMPRIN/CD147 Protein, Human, Recombinant (Avi & His), Biotinylated Human Human Cells
Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermato...
TMPY-01315 EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var...
TMPY-01316 EMMPRIN/CD147 Protein, Mouse, Recombinant (His) Mouse HEK293
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var...
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