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Rotigotine Hydrochloride

Catalog No. T21446 CAS 125572-93-2

Synonyms: Rotigotine (Hydrochloride), N 0923, N-0924, Rotigotine HCl, N-0923

Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.

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Rotigotine Hydrochloride Chemical Structure

Rotigotine Hydrochloride, CAS 125572-93-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 46.00
10 mg	In stock	$ 66.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 140.00
100 mg	In stock	$ 196.00
200 mg	In stock	$ 289.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 99.66%

Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.
Targets&IC50	α1B:273 nM (Ki), 5-HT7 receptor:86 nM (Ki), D1 receptor:83 nM (Ki), α2A:338 nM (Ki), D4 receptor:4-15 nM (Ki), D3 receptor:0.71 nM (Ki), 5-HT1A receptor:30 nM (Ki), α2B:27 nM (Ki), D5 receptor:4-15 nM (Ki), D2 receptor:4-15 nM (Ki), α1A:176 nM (Ki)

Synonyms	Rotigotine (Hydrochloride), N 0923, N-0924, Rotigotine HCl, N-0923
Molecular Weight	351.93
Formula	C19H26ClNOS
CAS No.	125572-93-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (142.07 mM)

References and Literature

1. Giladi N, Asgharnejad M, Bauer L, Grieger F, Boroojerdi B. Rotigotine in Combination with the MAO-B Inhibitor Selegiline in Early Parkinson's Disease: A Post Hoc Analysis. J Parkinsons Dis. 2016 Apr 2. [Epub ahead of print] PubMed PMID: 27061066. 2. Cannas A, Meloni M, Mascia MM,et al. Priapism and Hypersexuality Associated With Rotigotine in an Elderly Parkinsonian Patient: A Case Report. Clin Neuropharmacol. 2016 Apr 4. [Epub ahead of print] PubMed PMID: 27046660. 3. LeWitt PA, Poewe W, Elmer LW, et al. The Efficacy Profile of Rotigotine During the Waking Hours in Patients With Advanced Parkinson's Disease: A Post Hoc Analysis. Clin Neuropharmacol. 2016 Mar-Apr;39(2):88-93. 4. Dauvilliers Y, Benes H, Partinen M, Rauta V, Rifkin D, Dohin E, Goldammer N, Schollmayer E, Schröder H, Winkelman JW. Rotigotine in Hemodialysis-Associated Restless Legs Syndrome: A Randomized Controlled Trial. Am J Kidney Dis. 2016 Feb 2. pii: S0272-6386(16)00018-4.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library EMA Approved Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Drug Repurposing Compound Library Clinical Compound Library NO PAINS Compound Library

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Keywords

Rotigotine Hydrochloride 125572-93-2 GPCR/G Protein Neuroscience Adrenergic Receptor Dopamine Receptor 5-HT Receptor inhibit Inhibitor Rotigotine (Hydrochloride) N 0924 Rotigotine Serotonin Receptor N 0923 N-0924 Rotigotine HCl Beta Receptor 5-hydroxytryptamine Receptor N0924 N0923 N-0923 inhibitor

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