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Chlorprothixene

Catalog No. T0074 CAS 113-59-7

Synonyms: Truxal, Clorprotixeno, Taractan

Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized.

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Chlorprothixene, CAS 113-59-7

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25 mg	In stock	$ 38.00
100 mg	In stock	$ 63.00
200 mg	In stock	$ 88.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.69%

Purity: 98.77%

Biological Description

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Storage & Solubility Information

Description	Chlorprothixene (Truxal) is a typical antipsychotic drug of the thioxanthene class, which was the first of the series to be synthesized.
Targets&IC50	D2 receptor:2.96 nM(Ki), 5-HT6:3 nM(Ki), D3 receptor:4.56 nM(Ki), H1 receptor:3.75 nM(Ki), 5-HT7:5.6 nM(Ki)
In vitro	When Chlorprothixene acts on the brain, it inhibits the postsynaptic mesolimbic dopamine D1 and D2 receptors, reducing the release of hypothalamic and pituitary hormones. In mouse brains, Chlorprothixene reduces levels of 5HT, NE, and DA. At high doses, Chlorprothixene's effect on adrenal medulla and brain tissue can inhibit the action of nicotinic acid isopropylhydrazine, inducing the release of catecholamines for protective purposes. Additionally, Chlorprothixene has an inhibitory effect on acidic sphingomyelin in murine bronchial epithelial cells, promoting the repair of neuronal myelin concentration, thereby decreasing the incidence of inflammatory responses in mice with cystic fibrosis and also preventing infection by Pseudomonas aeruginosa.
In vivo	Chlorprothixene induces Vero 76 cells, resulting in inhibited replication of SARS-CoV. It exhibits high affinity for the murine 5-HT6 receptor in stably transfected HEK-293 cells, with a Ki value of 3 nM, and for the transiently expressed murine 5-HT7 receptor in COS-7 cells, with a Ki value of 5.6 nM. Chlorprothixene has a strong binding affinity to histamine and dopamine receptors including D1, D2, D3, D5, and H1, with Ki values of 18 nM, 2.96 nM, 4.56 nM, 9 nM, and 3.75 nM, respectively. However, its affinity for the H3 receptor is weak, with a Ki value greater than 1000 nM.

Synonyms	Truxal, Clorprotixeno, Taractan
Molecular Weight	315.86
Formula	C18H18ClNS
CAS No.	113-59-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 6 mg/mL (18.99 mM)

Ethanol: 27 mg/mL (85.5 mM)

References and Literature

1. von Coburg Y, et al. Bioorg Med Chem Lett. 2009, 19 (2), 538-542. 2. Roth BL, et al. J Pharmacol Exp Ther. 1994, 268 (3), 1403-1410. 3. Barnard DL, et al. Antiviral Res. 2008, 79 (2), 105-113. 4. GEY KF, et al. J Pharmacol Exp Ther. 1961, 133, 18-24. 5. Becker KA, et al. Am J Respir Cell Mol Biol, 2010, 42(6), 716-724.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library GPCR Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Human Metabolite Library Anti-Hypertension Compound Library

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Keywords

Chlorprothixene 113-59-7 GPCR/G Protein Immunology/Inflammation Microbiology/Virology Neuroscience Dopamine Receptor 5-HT Receptor Histamine Receptor Antibacterial Inhibitor Truxal inhibit Bacterial Clorprotixeno Taractan inhibitor

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