Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

AVN-101

AVN-101
AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases.
Catalog No. T26690Cas No. 1061354-48-0
Select Batch
Purity:99.73%
Contact us for more batch information
Resource Download

AVN-101

Catalog No. T26690Cas No. 1061354-48-0
AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$32In Stock
5 mg$73In Stock
10 mg$123In Stock
25 mg$228In Stock
50 mg$372In Stock
100 mg$619In Stock
1 mL x 10 mM (in DMSO)$98In Stock
Bulk & Custom
Add to Cart

Related Compound Libraries of "AVN-101"

Product Introduction

Bioactivity
Description
AVN-101 is a potent 5-HT7 receptor antagonist.
Targets&IC50
H1:0.58 nM(Ki), 5-HT7:153 pM(Ki), α2:0.41-3.6 nM(Ki)
Chemical Properties
Molecular Weight340.89
FormulaC21H25ClN2
Cas No.1061354-48-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/ml (176.01 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9335 mL14.6675 mL29.3350 mL146.6749 mL
5 mM0.5867 mL2.9335 mL5.8670 mL29.3350 mL
10 mM0.2933 mL1.4667 mL2.9335 mL14.6675 mL
20 mM0.1467 mL0.7334 mL1.4667 mL7.3337 mL
50 mM0.0587 mL0.2933 mL0.5867 mL2.9335 mL
100 mM0.0293 mL0.1467 mL0.2933 mL1.4667 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy AVN-101 | purchase AVN-101 | AVN-101 cost | order AVN-101 | AVN-101 chemical structure | AVN-101 formula | AVN-101 molecular weight