Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 336.00 | |
10 mg | In stock | $ 497.00 | |
25 mg | In stock | $ 793.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 345.00 |
Description | AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases. |
Targets&IC50 | α2:0.41-3.6 nM(Ki), H1:0.58 nM(Ki), 5-HT7:153 pM(Ki) |
Molecular Weight | 340.89 |
Formula | C21H25ClN2 |
CAS No. | 1061354-48-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (176.01 mM)
You can also refer to dose conversion for different animals. More
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AVN-101 1061354-48-0 GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Adrenergic Receptor Histamine Receptor AVN101 AVN 101 inhibitor inhibit