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Metergoline

Catalog No. T4008 CAS 17692-51-2

Synonyms: Methergoline, Liserdol

Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.

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Metergoline, CAS 17692-51-2

Pack Size	Availability	Price/USD	Quantity
10 mg	In stock	$ 35.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.83%

Purity: 99.7%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.

Synonyms	Methergoline, Liserdol
Molecular Weight	403.52
Formula	C25H29N3O2
CAS No.	17692-51-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40.4 mg/mL(100 mM)

References and Literature

1. Millan, M.J.,Newman-Tancredi, A.,Lochon, S., et al. Specific labelling of serotonin 5-HT1B receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. Pharmacol. Biochem. Behav. 71(4), 589-598 (2002). 2. Knight, A.R.,Misra, A.,Quirk, K., et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn Schmiedebergs Arch. Pharmacol. 370(2), 114-123 (2004) 3. Knight, J.A.,Smith, C.,Toohey, N., et al. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Mol. Pharmacol. 75(2), 374-380 (2009). 4. Yeom, H.D. and Lee, J.-H. Regulation of human Kv1.4 channel activity by the antidepressant metergoline. Biol. Pharm. Bull. 39(6), 1069-1072 (2016). 5. Lee, J.-H.,Liu, J.,Shin, M., et al. Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na+ channels expressed in Xenopus oocytes. Acta. Pharmacol. Sin. 35(7), 862-868 (2014).

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Serotonin Receptor-Targeted Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Metergoline 17692-51-2 GPCR/G Protein Membrane transporter/Ion channel Neuroscience Dopamine Receptor 5-HT Receptor Sodium Channel disorder inhibit affective hormone 5-hydroxytryptamine Receptor Na+ channels Na channels regulation Inhibitor dysphoric prolactin Serotonin Receptor premenstrual Methergoline psychoactive Liserdol inhibitor

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