Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,670.00 | |
50 mg | 6-8 weeks | $ 2,180.00 | |
100 mg | 6-8 weeks | $ 2,800.00 |
Description | AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). |
Targets&IC50 | 5-HT1D receptor:6.6 nM (ki), 5-HT5 receptor:98.5 nM (ki), 5-HT1A receptor:89.7 nM (ki), 5-HT7 receptor (human):0.6 nM (ki), 5-HT7 receptor (human):0.83 nM, 5-HT1B receptor:490 nM (ki) |
In vitro | The proliferation of T-cells from parachlorophenylalanine-treated mice is significantly reduced, the addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours [2]. |
In vivo | AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task [1]. |
Molecular Weight | 283.41 |
Formula | C18H25N3 |
CAS No. | 1000578-26-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AS19 1000578-26-6 GPCR/G Protein Neuroscience 5-HT Receptor AS 19 AS-19 inhibitor inhibit